Impact of Emotional Reactivity on Dysfunctional Decision-Making in NSSI Adolescents

Nonsuicidal Self Injury Clinical Trial

Official title:

Effects of Emotional Reactivity on Decision-Making in Adolescents With Nonsuicidal Self-Injury

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05981612
• Other study ID #: BAM_lab_NSSI_04
• Status: Recruiting
• Start date: December 6, 2023
• Est. completion date: July 2027

Study information

• Verified date: April 2024
• Source: University of Electronic Science and Technology of China
• Contact: Benjamin Becker
• Phone: +86.028-61830867
• Email: ben_becker[@]gmx.de
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Nonsuicidal self-injury (NSSI) is defined as direct, intentional physical injury without suicidal intention. Studies revealed that dysfunctional interpersonal relationships and reward-related decision-making may play crucial roles in this maladaptive behavior, especially in adolescents. These interpersonal decision contexts are characterized by constant updating of expectations of rewards and the actual received rewards as well as the associated emotional reactions. These processes have recently been computationally formalized as prediction errors (PE), specifically reward PEs, valence PEs, and arousal PEs (Heffner et al., 2021; Nat Hum Behav). In the current study, the investigators aim to investigate whether these PEs make discernible contributions to social decisions in the context of unfair experiences among adolescents with NSSI and matched healthy control adolescents (HC). Specifically the investigators hypothesized that: 1) reward and emotional PEs show significant predictions of punishment decisions in both groups, 2) however, compared to HC adolescents, the NSSI group will exhibit selective dysfunctions in emotional but not reward PEs leading to punish a norm proposer who provided unfair offers.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: July 2027
• Est. primary completion date: July 2026
• Gender: All
• Age group: 15 Years to 18 Years

Eligibility

Inclusion Criteria:

• 15-18 years
• right-handed
• normal or corrected normal visual acuity
• meet the proposed DSM-5 frequency criteria (e.g., =5 days of NSSI behaviors in the past year)

Exclusion Criteria:

• diagnosis of borderline personality disorder, major depressive disorder, other
• psychiatric disorders, etc.
• high suicidal risk
• recent use of medications that can affect neural activity
• have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months
• have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)

Related Conditions & MeSH terms

• Nonsuicidal Self Injury
• Self-Injurious Behavior

Locations

Country	Name	City	State
China	Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China	Chengdu	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
University of Electronic Science and Technology of China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reward prediction errors (PEs)	Reward PEs will be calculated by the differences between the experienced (when be offered) reward and predicted (before the offer) reward.	About 20 minutes
Primary	Valence prediction errors (PEs)	Valence PEs will be calculated by the differences between the experienced emotional valence and predicted emotional valence.	About 20 minutes
Primary	Arousal prediction errors (PEs)	Arousal PEs will be calculated by the differences between the experienced emotional arousal and predicted emotional arousal.	About 20 minutes
Primary	The prediction of PEs of punishment decisions	All PEs and groups (NSSI, HC) will be used in a regression model to examined whether there is any alteration in the NSSI group when PEs are predicted to punishment (reject) decisions.	About 20 minutes