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Non-Smoking clinical trials

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NCT ID: NCT03784742 Completed - Non-smoking Clinical Trials

Effects of Daily Nitrate Consumption on Oral Bacteria Composition, Blood Pressure and Vascular Function

REBOC2
Start date: December 1, 2018
Phase: N/A
Study type: Interventional

Diseases of the heart and blood vessels, including raised blood pressure, are one of the leading causes of death worldwide. Higher intakes of dietary nitrate, found abundantly in root vegetables such as beetroot, have been shown to have health benefits including lowering blood pressure and improving the elasticity of blood vessels. Bacteria which reside in the mouth and those in the gastrointestinal tract play an important role in converting dietary nitrate to nitrite and nitric oxide (a chemical which promotes the relaxation of blood vessels). In particular, removal of oral bacteria by using antiseptic mouthwash is accompanied by an increase in blood pressure in subjects with normal blood pressure, even after consuming nitrate-rich foods. To date, very little is known about the role of these oral bacteria in the control of blood pressure, and if there are any differences in bacterial composition between individuals.

NCT ID: NCT01465880 Completed - Smoking Clinical Trials

Smoking Research Study

Start date: July 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to develop a fit-for-purpose biochemical verification tool that can be used to detect concomitant use of a few (less than 5) conventional cigarettes.

NCT ID: NCT00694044 Completed - Healthy Clinical Trials

Evaluation of Varenicline Safety, Tolerability, Pharmacokinetics and Pro-Cognitive Effects in Healthy Elderly Non-Smoking Subjects

Start date: April 2008
Phase: Phase 1
Study type: Interventional

1. Characterize the tolerability and safety of repeated doses of varenicline in healthy non-smoking elderly subjects. 2. Describe the steady state pharmacokinetics of varenicline in healthy non-smoking elderly subjects. 3. Evaluate the potential effects of repeat doses of varenicline on cognition in healtly non-smoking elderly subjects.