DaHuang GangTsao Tang to Improve the Appetite Loss Condition of Cancer Patients

Non-organic Loss of Appetite Clinical Trial

— TCM  

Official title:

Taking Herbal Formula：DaHuang GangTsao Tang to Improve the Appetite Loss Condition of Cancer Patients in Late-stage：A Clinical Control Trial Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01503346
• Other study ID #: 100610
• Secondary ID: Protocol Record
• Status: Completed
• Phase: Phase 2
• Start date: March 2011
• Est. completion date: March 2013

Study information

• Verified date: February 2020
• Source: Changhua Christian Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Appetite loss is a severe and common symptom among late-stage cancer patients, and it causes great the anxiety for the patient's family. In TCM theory, the investigators call these patients are in block and repulsion condition. The investigators try to set a study to use the herbal medicine solution taken in frequent small amounts by cancer patients in late-stage to improve the appetite loss condition. Through this method, the investigators not only want to improve the quality of life of cancer patients in late-stage but also set a valuable treatment.

Description:

Intervention group

• 1. 2 grams of DaHuang abstract powder and 0.5 grams GanTsao abstract powder are mixed and separated into four packages;

• 2. each package was given to each patient four times a day (three time after meal and one time before sleep);

• 3. each patient received the usual medication of the hospice ward at the same time;

• 4. record the patients' score of pre-test, mid-test and after-test of QIPCTP at the 1st day, the 3rd day and the 6th day;

• 5. record the patients' score of EORTC QLQ-C30 V3.0 and ECOG (Eastern Cooperative Oncology Group Performance Status) at the 1st day and the 6th day.

Control group

• 1. each patient received the usual medication of the hospice ward during the trial interval;

• 2. record the patients' score of receive pre-test, mid-test and after-test of QIPCTP at the 1st day, the 3rd day and the 6th day;

• 3. record the patients' score of EORTC QLQ-C30 V3.0 and ECOG (Eastern Cooperative Oncology Group Performance Status) at at the 1st day and the 6th day.

Medicine DaHuang herbal abstract powder is produced by Sun Ten Pharmaceutical Co., Ltd, and it's product serial number: 276001. GanCao herbal abstract powder is also produced by Sun Ten Pharmaceutical Co., Ltd, and it's product serial number: 185645. Each herbal abstract powder is qualified with the data of HPLC to confirm each content and stability. The pharmaceutical company is qualified by Good Manufacturing Practice (GMP) certification in Taiwan.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 4
• Est. completion date: March 2013
• Est. primary completion date: September 2011
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• Terminal cancer patients in hospice ward

• Patients with appetite loss condition

• Ages between 20 to 80 years old

• No history of diabetes

Exclusion Criteria:

• Entered the stage of dying patients

• Receiving other traditional Chinese medicine

Related Conditions & MeSH terms

• Anorexia
• Non-organic Loss of Appetite

Intervention

Drug:
• DaHuang GanTsao Tang
Intervention group 2 grams of DaHuang abstract powder and 0.5 grams GanTsao abstract powder are mixed and separated into four packages; each package was given to each patient four times a day (three time after meal and one time before sleep); each patient received the usual medication of the hospice ward at the same time; record the patients' score of pre-test, mid-test and after-test of QIPCTP at the 1st day, the 3rd day and the 6th day; record the patients' score of EORTC QLQ-C30 V3.0 and ECOG (Eastern Cooperative Oncology Group Performance Status) at the 1st day and the 6th day.

Locations

Country	Name	City	State
Taiwan	Changhua Christan Hospital	Changhua City	Changhua Country

Sponsors (1)

Lead Sponsor	Collaborator
Changhua Christian Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	appetite score	The investigators detect the patients' appetite condition at the 1st,3rd and 6th day.	6 days