| Eligibility |
Inclusion Criteria:
- Adult Females (= 18 years), with effective contraception. The contraceptive should not
use estrogen to a derivative. It must be continued during treatment with tamoxifen for
at least two months after his arrest.
- Histologically confirmed diagnosis of invasive breast cancer, previously untreated.
Patients have been supported for a breast cancer may be included if a period of at
least 2 years between the last systemic treatment of inclusion in the study.
- Primary tumor hormonopositive: ER and / or PR = 50% by immunohistochemistry.
- Lack of HER2 overexpression
- Palpable primary tumor or greater than or equal to 20 mm in diameter, measured by
ultrasound
- Patient scheduled to undergo breast cancer surgery
- No metastases
- Clinical Stage M0
- Performance index = 1 (OMS)
- Neutrophils WBC > or = 1500 / mm3, Platelets > or = 100 000/mm3 Hemoglobin =10 g/dL
- Normal liver function: bilirubin = 1.5 x ULN, aspartate aminotransferase (AST) and
alanine aminotransferase (ALT) = 2.5 x ULN (= 5 x ULN if liver metastases).
- Normal renal function (creatinine = 1.5 mg / dL or creatinine clearance = 60 mL / min)
- Cardiac function (MUGA scan or ultrasound February> 55%) and lung function, 5.2.2
Criteria related to participation in the study:
- Patient affiliated to social security, Patient has signed and dated consent
Non-Inclusion Criteria:
1. Pregnant or Breastfeeding women
2. Use of St. John's Wort (herbal tea ...) within 5 days before starting treatment
3. Consumption of grapefruit juice in the last 5 days of starting treatment
4. Congenital galactosemia
5. Glucose and galactose malabsorption
6. Lactase deficiency
7. Co-medications that may interfere with cytochrome P450:
8. Ongoing Enzyme inducers:
- Antiepileptic drugs: carbamazepine, phenobarbital, phenytoin
- Antinfectieux: rifampin, rifabutin, névrirapine, griséofilvine, efavirenz
9. Ongoing Enzyme Inhibitors:
- Inhibitors of serotonin reuptake: fluoxetine, paroxetine
- Thioridazine. Quinidine
- Amiodarone
- Ca antagonists: diltiazem, verapamil
- azole antifungals ketoconazole, fluconazole, miconazole.
- No protease inhibitors: ritonavir, nelfinavir, amprenavir, indinavir.
- Macrolides: erythromycin, clarithromycin, josamycin
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