Clinical Trials Logo
  1. Home
  2. Non-infectious Uveitis
  3. NCT03634475

A Safety Study of Intravitreal PP-001 in Patients With Chronic, Non-Infectious Uveitis

Non-infectious Uveitis Clinical Trial

Official title:
A Safety Study of Intravitreal PP-001 in Patients With Chronic, Non-Infectious Uveitis Having Chronic Inflammation

Clinical Trial Summary

In this study, PP-001 is assessed for safety and efficacy in patients diagnosed with non-infectious chronic uveitis. PP-001 is a novel small molecule that inhibits a specific enzyme (Dihydroorotate Dehydrogenase) and has shown pre-clinical efficacy in treatment of non-infectious uveitis. PP-001 will be administered to participants as a single intravitreal injection in ascending doses.

Clinical Trial Description

This study assesses safety and efficacy of PP-001 after intravitreal injection in patients diagnosed with non-infectious chronic uveitis. PP-001 is a novel small molecule inhibitor of Dihydroorotate Dehydrogenase (DHODH) and has shown pre-clinical efficacy in treatment of non-infectious uveitis. PP-001 is to offer a local treatment alternative to corticosteroids with the objective to reduce or possibly replace steroid intake of non-infectious uveitis patients. In the current study, PP-001 will be injected in ascending doses into the vitreous body of the eye of study participants who suffer from non-infectious uveitis. Participants will be monitored for safety and efficacy evaluation of the study drug. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03634475
Study type Interventional
Source Panoptes Pharma GmbH
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date January 2017
Completion date December 2020
View Details
See also
  Status Clinical Trial Phase
Not yet recruiting NCT05928754 - Prospective CoHoRt Of Non-infectious Intermediate, pOsterior or panuveitiS N/A
Terminated NCT00646425 - The Safety and Efficacy of Basiliximab as Maintenance Therapy in Subjects With Stable, Noninfectious Uveitis Phase 2
Terminated NCT00456482 - Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implant Phase 2/Phase 3
Recruiting NCT00720928 - Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Phase 4
Completed NCT04018599 - Comparison of PK and Tolerability of MSB11022 Administered by AI or PFS Phase 1
Terminated NCT02951975 - Ozurdex® in Patients With Non-infectious Uveitis Affecting the Posterior Segment of the Eye
Completed NCT04207983 - A 48 Week Study to Evaluate the Efficacy and Safety of Two (2) EYS606 Treatment Regimens in Subjects With Active Chronic Non-infectious Uveitis (CNIU) Phase 2
Completed NCT02748512 - Utilization and Safety of the Mk II Inserter and the Safety of the FAI Insert in Non-Infectious Uveitis Phase 3
Recruiting NCT02706704 - Intravitreal Adalimumab Versus Subcutaneous Adalimumab in Non-infectious Uveitis Phase 2
Terminated NCT01032915 - Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Phase 3
Not yet recruiting NCT04105452 - Study to Evaluate PL8177 in Subjects With Non Infectious Uveitis (NIU) Phase 2
Terminated NCT01090310 - Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis Phase 3
Completed NCT01694186 - Safety and Efficacy of an Injectable Fluocinolone Acetonide Intravitreal Insert Phase 3
Completed NCT03308045 - Evaluation of EYS606 in Patients With Non-infectious Posterior, Intermediate or Panuveitis Phase 1/Phase 2
Completed NCT00468871 - Safety and Efficacy of Fluocinolone Acetonide Intravitreal Implant vs Standardized Therapy Phase 2/Phase 3