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Clinical Trial Summary

SC262-101 is a Phase 1 study to evaluate SC262 safety and tolerability, anti-tumor activity, cellular kinetics, immunogenicity, and exploratory biomarkers.


Clinical Trial Description

This is an open-label, single arm, Phase 1, first-in-human (FIH) study to evaluate the safety and tolerability of SC262 administered intravenously (IV) following a standard lymphodepleting chemotherapy regimen of cyclophosphamide and fludarabine in subjects with Non Hodgkin's Lymphoma (NHL) who have received no more than 1 prior CD19-directed Chimeric Antigen Receptor T-Cells (CAR T) cell therapy. This study will be conducted in 2 parts. Dose finding using a 3+3 design in subjects with NHL. Dose expansion to further evaluate safety and efficacy at the recommended phase 2 dose (RP2D) in subjects with Large B-Cell Lymphoma (LBCL). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06285422
Study type Interventional
Source Sana Biotechnology
Contact Ndidi Onwudiwe
Phone (206) 791 3731
Email vivid@sana.com
Status Recruiting
Phase Phase 1
Start date May 2024
Completion date March 2029

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