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Clinical Trial Summary

This is a single-center, single-arm pilot trial designed to evaluate the expression of PD-L1 in patients with Large B-cell lymphoma (LBCL) and its role in non-responsiveness to chimeric antigen receptor (CAR) T-cell therapy in a non-invasive manner. Moreover, within this trial 89Zr-atezolizumab PET/CT imaging as a tool to distinguish lymphoma activity from a treatment-related inflammatory signal (histiocytic/sarcoid-like reaction) in patients with an end-of-treatment positive FDG PET/CT signal will be evaluated.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05404048
Study type Interventional
Source University Medical Center Groningen
Contact Janneke W de Boer, MD
Phone +31625573522
Email j.w.de.boer@umcg.nl
Status Recruiting
Phase Phase 2
Start date May 18, 2022
Completion date May 2025

See also
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