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Clinical Trial Summary

This is an open-label, multicenter, Phase 1/2 study evaluating the safety and efficacy of CTX110 in subjects with relapsed or refractory B-cell malignancies.


Clinical Trial Description

The study may enroll up to 227 subjects in total. CTX110 is a CD19-directed chimeric antigen receptor (CAR) T cell immunotherapy comprised of allogeneic T cells prepared for the treatment of B cell malignancies. The cells are from healthy adult volunteer donors that are genetically modified ex vivo using CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats/ CRISPR-associated protein 9) gene editing components (single guide RNA and Cas9 nuclease). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04035434
Study type Interventional
Source CRISPR Therapeutics
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date July 22, 2019
Completion date August 2026

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