Non-Alcoholic Fatty Liver Disease Clinical Trial
Official title:
Mediterranean Diet Versus Paleolithic Diet for the Treatment of Non Alcohlic Fatty
Non- alcoholic fatty liver disease (NAFLD) is one of metabolic syndrome manifestation, and
has become the leading cause for cirrhosis and the need for liver transplantation.
The Mediterranean diet showed in many trials its benefit in the treatment of the metabolic
syndrome and NAFLD. The Paleolithic Diet includes meat, fish, fruits, vegetables, nuts and
seeds and avoidance of processed food and most of carbohydrates. In some studies this diet
seemed to decrease triglycerides levels and improve insulin resistance.
The aim of this study is to evaluate the influance of the paleolithic diat for the treatment
of NAFLD, as shown in the Mediterranean Diet.
Recruitment of 60 patients with the diagnosis NAFLD from clinics in Rabin Medical center,
aged 18-65.
Two study groups- Mediterranean Diet and Paleolithic Diet The dietitian will assign randomly
for the study groups, and will assess diet adherence within 6 weeks of the trial and in its
end- after 3 months.
blood test for liver enzymes, lipids, crp, mda and HbA1C, will be taken at recruitment and
after 3 months.
Ultrasound and elastography will be tested at recruitment and after 3 months, to evaluate the
degree of the fatty liver, by a the same doctor who is blind to the study groups.
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