Non-Alcoholic Fatty Liver Disease Clinical Trial
Official title:
Combining MRI Steatosis Assessment and Transient Elastography to Improve Liver Fibrosis Diagnosis in Non-Alcoholic Fatty Liver Disease (NAFLD)
The main objective is to compare the accuracy of transient elastography taking into account liver steatosis determined by MRI, to liver biopsy for the diagnosis of liver fibrosis ≥F2 in patient with NAFLD.
No alcoholic fatty liver disease (NAFLD) is induced by an abnormal build up of fat in the
liver. It can induce liver damage, namely fibrosis, which leads to cirrhosis and an increased
risk of liver cancer. The diagnosis of liver fibrosis is thus critical to identify patients
at risk.
Liver biopsy is the gold standard for the diagnosis of liver fibrosis. However this invasive
test is expensive and has a significant morbidity.
To avoid this others non invasive test have been developed to assess steatosis and fibrosis
of the liver :
- Magnetic Resonance Imaging can quantify liver steatosis accurately.
- Transient elastography (Fibroscan®) is approved for the diagnosis of fibrosis in chronic
hepatitis C. However results in NAFLD were disappointing. Further, steatosis by
heightening liver elasticity is thought to be the cause of these poor results.
- Several biological tests or score are also approved in chronic hepatitis C, but not in
NAFLD.
The hypothesis driving this study is that by accounting for liver steatosis through the mean
of MRI, we could more accurately interpret transient elastography value to accurately
diagnose the severity of liver fibrosis.
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