MUltimodal Targeted Axillary Surgery — MUTAS  

Node-positive Breast Cancer Clinical Trial

Official title: Prospective Trial to Evaluate MUltimodal Targeted Axillary Surgery (MUTAS) Approaches in Breast Cancer Patients With Positive Lymph Nodes.

Status Recruiting

Clinical Trial Summary

The present trial will prospectively evaluate the accuracy of both a systematic predefined axillary ultrasound imaging together with tumor load quantification of suspicious and sentinel axillary lymph nodes to predict overall tumor load in the axilla.

Clinical Trial Description

Axillary node clearance (ANC) is a controversial intervention in the surgical treatment of breast cancer. Different studies have shown that in some patients with infiltrated axillary lymph nodes but low tumor burden, ANC can be safely omitted. However, indications for ANC persist in nowadays for patients with positive axillary lymph nodes and upfront surgery and patients with positive lymph nodes after neoadjuvant treatment. The present prospective study will evaluate the ability to establish an axillary tumor load with two steps. The first step will be a preoperative predefined systematic axillary ultrasound imaging workflow. The second step will be the tumor load evaluation of suspicious and sentinel axillary lymph nodes. We will also evaluate which patients have infiltrated nodes only beneath the second intercostobrachial nerve. The trial intends to identify patients for who a complete axillary node clearance could be spared. ;

Related Conditions & MeSH terms

• Breast Neoplasms
• Node-positive Breast Cancer

• NCT number: NCT04039893
• Study type: Interventional
• Source: Parc de Salut Mar
• Contact: Maria Vernet-Tomas, MD, PhD
• Phone: 34932483132
• Email: mvernet@psmar.cat
• Status: Recruiting
• Phase: N/A
• Start date: October 23, 2019
• Completion date: November 15, 2022