Nicotine Clinical Trial
Official title:
The Acute Cardiovascular Effects of Nicotine in E-cigarettes (ACE) Study
The goal of this project is to evaluate the nicotine induced acute cardiovascular changes in E-Cigarette users and also study the mechanism involved particularly with vascular impairment.
We will recruit 30 experienced E-cigarette users (those using E-Cigarette for at least 1
month and ≤ 1 tobacco cigarette / day), between ages 21-40 years; in 4 day study visit and 10
non-smokers (those who used less than 100 tobacco cigarettes in their lifetime and not active
nicotine/tobacco or related product user) for a one study visit.The participants will be
asked to abstain from all tobacco/nicotine and related product use for 12 hours before each
visit.
Measurements will be taken at each study visit before and after E-cigarette use, each day
with different nicotine dose, to look at both the individuals' exposure to nicotine and also
the effects on the cardiovascular system. These measurements will include blood and urine
samples as well as non-invasive cardiovascular measurements.
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