United States Pre-Market Tobacco Application Pharmacokinetics — US-PMTA-PK  

Nicotine Dependence Clinical Trial

Official title: A Randomized, Open-Label, Cross-Over Study to Assess Nicotine Uptake and Subjective Measures With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) Compared to Usual Brand Combustible Cigarettes, a Comparator E-Cigarette, and Nicotine Gum in Healthy Adult Smokers

Status Completed

Clinical Trial Summary

A Randomized, Open-Label, Cross-Over Study to Assess Nicotine Uptake and Subjective Measures with Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) Compared to Usual Brand Combustible Cigarettes, a Comparator E-Cigarette, and Nicotine Gum in Healthy Adult Smokers

Clinical Trial Description

E-cigarettes may be an acceptable alternative to traditional cigarette smoking. In utilizing vaporization rather than combustion, the generation and inhaltion of smoke and carbon monoxide (CO) may be reduced or avoided. JUUL has developed several nicotine based liquid blends for use in e-cigarettes. This study will assess nicotine uptake during a 10-puff controlled and a 5-minute ad libitum use of four JUUL 5% electronic nicotine delivery systems (ENDS) relative to usual brand (UB) combustible cigarettes, a comparator electronic cigarette (e-cigarette), and nicotine gum. ;

Related Conditions & MeSH terms

• Nicotine Dependence
• Nicotine Dependence, Cigarettes
• Tobacco Smoking
• Tobacco Use
• Tobacco Use Disorder

• NCT number: NCT03719391
• Study type: Interventional
• Source: Juul Labs, Inc.
• Status: Completed
• Phase: N/A
• Start date: October 19, 2018
• Completion date: November 28, 2018