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Clinical Trial Summary

This study will evaluate the safety, tolerability, and efficacy of oral KPT-9274 for the treatment of patients with advanced solid malignancies or non-Hodgkin's lymphoma (NHL). Currently enrolling melanoma patients in combination with nivolumab, only.


Clinical Trial Description

This is a first-in-human, multi-center, open-label clinical study with separate Dose Escalation and Expansion Phases to assess preliminary safety, tolerability, and efficacy of KPT-9274, a dual inhibitor of PAK4 and NAMPT, in patients with advanced solid malignancies (including sarcoma, colon, lung, melanoma, etc.) or NHL for which all standard therapeutic options considered useful by the investigator have been exhausted. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02702492
Study type Interventional
Source Karyopharm Therapeutics Inc
Contact
Status Terminated
Phase Phase 1
Start date June 2016
Completion date June 1, 2021

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