Neurotoxic Effect of Sevoflurane-Based Anaesthesia Clinical Trial
Official title:
Evaluation of Neurotoxic Effect of Sevoflurane‑Based Anaesthesia Guided by Significant Short‑Term Olfactory Identification Impairment in Old Age
Nowadays there is increasing doubts about the safety of anesthesia . Anesthesiologists have to console the worried patients, who are anxious about the potential risks of anesthetic-induced brain damage, by suggesting that any detrimental effects would be "mild".Anesthetics are responsible for postoperative taste and odor defects and cognitive dysfunction.
Aims: The aim of this study is to assess the effect of isoflurane, sevoflurane, propofol and
regional anesthesia on the olfactory threshold, olfactory identification and endocrine
regulation of associative memory in the postoperative period in old age group.
Methods: 600 patients (> 60years ) fulfilling the criteria of the American society of
anesthesiologists and II status were selected for this prospective single-blinded randomized
controlled study. Patients were randomized into one of four groups to receive regional
anesthesia (control group), general anesthesia with sevoflurane, general anesthesia with
isoflurane and total intravenous anesthesia with propofol.
Mini-Mental State Examination (MMSE), olfactory threshold, and olfactory identification were
tested at 12 hours preoperatively (T0), at 3 hours postoperatively (T1) and at the time of
discharge or postoperative 3 days (T2). In addition, serum melatonin levels were estimated at
T0 and T1.
N‑butyl alcohol was used to test the olfactory threshold and the Pocket Smell Test TM series
(PSTs) was used to test olfactory identification. Data were analyzed using the one‑way
analysis of variance, Kruskal‑Wallis or Mann‑Whitney tests.
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