Characterization and Differential Diagnosis of Postneurosurgical Meningitis

Neurosurgery Clinical Trial

Official title:

Clinical Features, Microbiological Characteristics, and Differential Diagnosis of Postneurosurgical Meningitis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01122537
• Other study ID #: APNSM
• Status: Completed
• Phase: N/A
• First received: May 11, 2010
• Last updated: September 29, 2013
• Start date: May 2010
• Est. completion date: September 2013

Study information

• Verified date: September 2013
• Source: Asan Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Korea: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.

Description:

Besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (CSF) culture, and profiles of blood and CSF inflammatory markers for the differential diagnosis of meningitis. CSF culture will be extended upto 2 weeks. Serum procalcitonin and C-reactive protein, CSF adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 78
• Est. completion date: September 2013
• Est. primary completion date: September 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 16 Years and older

Eligibility

Inclusion Criteria:

• Cerebrospinal fluid corrected WBC >6/mm^3 and/or fever (> 38?) and/or neck stiffness

Exclusion Criteria:

• Patients already treated more than 48 hours for meningitis before cerebrospinal fluid examination

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Meningitis
• Neurosurgery

Locations

Country	Name	City	State
Korea, Republic of	Asan Medical Center	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Asan Medical Center

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Development of meningitis		within 4 weeks after neurosurgical operation	No
Secondary	All-cause mortality		within 4 weeks after the diagnosis of meningitis	No