Effect of Topical Lidocaine on Warm and Cold Sensation in Healthy Individuals

Neuropathy;Peripheral Clinical Trial

Official title: Effect of Topical Lidocaine on Warm and Cold Sensation in Healthy Individuals - a Randomized Crossover Trial

Status Recruiting

Clinical Trial Summary

The purpose of the present study is to systematically test the occurrence of paradoxical and illusory responses to cold and warm stimuli in healthy volunteers with artificial sensory loss.

Clinical Trial Description

Efficient thermal sensation is important for adequate behavioral response to cold or warm stimuli and early signs of neuropathy can be changes in the thermal sensation.

Alterations in thermal perception can results in paradoxical heat sensation (a warm perception when the skin is cooled) or a peculiar/burning sensation when the skin is stiumlated with simultaneous warm and cold (a "thermal grill").

Clarifying the occurrence of these paradoxical and illusory sensations, may help understanding early signs of peripheral neuropathy as well as thermal sensory perception.

The investigators plan to conduct a study on thermal sensory perception using a model of sensory loss in healthy volunteers and systematically test the occurrence of paradoxical heat sensations and responses to the thermal grill. ;

Related Conditions & MeSH terms

• Hypesthesia
• Neuropathy;Peripheral
• Peripheral Nervous System Diseases

• NCT number: NCT04865185
• Study type: Interventional
• Source: University of Aarhus
• Contact: Ellen L Schaldemose, MD
• Phone: +45 93501942
• Email: ells@clin.au.dk
• Status: Recruiting
• Phase: N/A
• Start date: March 1, 2021
• Completion date: February 28, 2022