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Clinical Trial Summary

The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.


Clinical Trial Description

Sinus-like electrical stimulation may depolarize unmyelinated skin nociceptors involving NaV1.7 channels. In this case electrical stimulation may provoke pain already with very low currency intensity which normally not provoke pain in healthy subjects. This may be predictive for pain relief due to the sodium channel blocker lidocaine 5% patch. The study will characterize pain states in peripheral neuropathic pain as well as within the painful scar in chronic postoperative pain with regard to the involvement of NaV1.7 channels. In addition, the pain site in chronic postoperative pain (scar) will be characterized by laser-evoked potentials (LEP) and quantitative sensory testing (QST). Pain related questionnaires will be obtained. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03037684
Study type Observational
Source Swiss Paraplegic Research, Nottwil
Contact Gunther Landmann, MD
Phone +4141939
Email gunther.landmann@paraplegie.ch
Status Recruiting
Phase
Start date March 27, 2017
Completion date December 31, 2024

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