Neuropathy;Peripheral Clinical Trial
Official title:
Selective Activation of Unmyelinated Skin Nerve Fibres Using Slow Depolarising Transcutaneous Electrical Stimulation in Patients With Neuropathic Pain or Chronic Postoperative Pain
The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.
Sinus-like electrical stimulation may depolarize unmyelinated skin nociceptors involving NaV1.7 channels. In this case electrical stimulation may provoke pain already with very low currency intensity which normally not provoke pain in healthy subjects. This may be predictive for pain relief due to the sodium channel blocker lidocaine 5% patch. The study will characterize pain states in peripheral neuropathic pain as well as within the painful scar in chronic postoperative pain with regard to the involvement of NaV1.7 channels. In addition, the pain site in chronic postoperative pain (scar) will be characterized by laser-evoked potentials (LEP) and quantitative sensory testing (QST). Pain related questionnaires will be obtained. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04699734 -
Peripheral Nerve Block in Patients With Painful Diabetic Polyneuropathy
|
N/A | |
Completed |
NCT04054804 -
Digital Foot Check by Using the D-Foot, a New Software
|
||
Completed |
NCT05161364 -
Kinetic Analysis Due to Foot Dysfunction
|
||
Not yet recruiting |
NCT03899298 -
Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions
|
Phase 1 | |
Completed |
NCT02970006 -
Investigating Mechanisms Underlying Spinal Cord Stimulation Efficacy Using Virtual Reality and Full Body Illusion
|
N/A | |
Recruiting |
NCT05291286 -
BXQ-350 Pharmacokinetic/Pharmacodynamic Study in Cancer Patients
|
Early Phase 1 | |
Recruiting |
NCT04403802 -
Voxx Human Performance Technology Socks for Chemotherapy-Induced Peripheral Neuropathy
|
N/A | |
Enrolling by invitation |
NCT05590117 -
Protective Effect of Pentoxifylline Against Chemotherapy Induced Toxicities in Patients With Colorectal Cancer
|
Early Phase 1 | |
Recruiting |
NCT05624138 -
The Possible Protective Role of Ketotifen Against Oxaliplatin Induced Peripheral Neuropathy
|
Phase 3 | |
Recruiting |
NCT06121232 -
Exploring the Benefit of Neuromodulation in Treating Chemo-induced Peripheral Neuropathy Using Peripheral Neuropathy Markers (Meissner's Corpuscles and Epidermal Nerve Fiber Density) and Sensory Testing (Quantitative Sensory and Gait Testing): A Single Center Feasibility Study
|
N/A | |
Recruiting |
NCT05065554 -
ACALA-R In Predominantly Demyelinating IgM Mediated Neuropathy
|
Phase 2 | |
Recruiting |
NCT05980767 -
Short Duration Electrical Stimulation to Improve Outcomes After Cubital Tunnel Release (SELECT) Trial
|
N/A | |
Completed |
NCT03135535 -
Micro-mobile Foot Compression and Diabetic Foot
|
Phase 2 | |
Recruiting |
NCT04865185 -
Effect of Topical Lidocaine on Warm and Cold Sensation in Healthy Individuals
|
N/A | |
Completed |
NCT05093023 -
ABCB1 SNPs as Predictors of PIPN
|
||
Completed |
NCT05410548 -
Comorbidity Screening and Referral by Prosthetists
|
N/A | |
Completed |
NCT03021174 -
Exercise and Nutrition Interventions During Chemotherapy
|
N/A | |
Not yet recruiting |
NCT06422949 -
Efficacy and Safety of HILOTERM® Device for the Prevention of Peripheral Neuropathy
|
N/A | |
Terminated |
NCT03777956 -
The Effect of Lacosamide in Peripheral Neuropathic Pain
|
Phase 2 | |
Terminated |
NCT04218448 -
Evaluation of the Interest of Hypno-relaxation During Somatosensory Evoked Potentials
|
N/A |