Clinical Trials Logo

Clinical Trial Summary

The aim of the study is to evaluate voltage gated sodium channel (NaV1.7) dependent pain phenomena in neuropathic pain and chronic postoperative pain.


Clinical Trial Description

Sinus-like electrical stimulation may depolarize unmyelinated skin nociceptors involving NaV1.7 channels. In this case electrical stimulation may provoke pain already with very low currency intensity which normally not provoke pain in healthy subjects. This may be predictive for pain relief due to the sodium channel blocker lidocaine 5% patch. The study will characterize pain states in peripheral neuropathic pain as well as within the painful scar in chronic postoperative pain with regard to the involvement of NaV1.7 channels. In addition, the pain site in chronic postoperative pain (scar) will be characterized by laser-evoked potentials (LEP) and quantitative sensory testing (QST). Pain related questionnaires will be obtained. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03037684
Study type Observational
Source Swiss Paraplegic Research, Nottwil
Contact Gunther Landmann, MD
Phone +4141939
Email gunther.landmann@paraplegie.ch
Status Recruiting
Phase
Start date March 27, 2017
Completion date December 31, 2024

See also
  Status Clinical Trial Phase
Recruiting NCT04699734 - Peripheral Nerve Block in Patients With Painful Diabetic Polyneuropathy N/A
Completed NCT04054804 - Digital Foot Check by Using the D-Foot, a New Software
Completed NCT05161364 - Kinetic Analysis Due to Foot Dysfunction
Not yet recruiting NCT03899298 - Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions Phase 1
Completed NCT02970006 - Investigating Mechanisms Underlying Spinal Cord Stimulation Efficacy Using Virtual Reality and Full Body Illusion N/A
Recruiting NCT05291286 - BXQ-350 Pharmacokinetic/Pharmacodynamic Study in Cancer Patients Early Phase 1
Recruiting NCT04403802 - Voxx Human Performance Technology Socks for Chemotherapy-Induced Peripheral Neuropathy N/A
Enrolling by invitation NCT05590117 - Protective Effect of Pentoxifylline Against Chemotherapy Induced Toxicities in Patients With Colorectal Cancer Early Phase 1
Recruiting NCT05624138 - The Possible Protective Role of Ketotifen Against Oxaliplatin Induced Peripheral Neuropathy Phase 3
Recruiting NCT06121232 - Exploring the Benefit of Neuromodulation in Treating Chemo-induced Peripheral Neuropathy Using Peripheral Neuropathy Markers (Meissner's Corpuscles and Epidermal Nerve Fiber Density) and Sensory Testing (Quantitative Sensory and Gait Testing): A Single Center Feasibility Study N/A
Recruiting NCT05065554 - ACALA-R In Predominantly Demyelinating IgM Mediated Neuropathy Phase 2
Recruiting NCT05980767 - Short Duration Electrical Stimulation to Improve Outcomes After Cubital Tunnel Release (SELECT) Trial N/A
Completed NCT03135535 - Micro-mobile Foot Compression and Diabetic Foot Phase 2
Recruiting NCT04865185 - Effect of Topical Lidocaine on Warm and Cold Sensation in Healthy Individuals N/A
Completed NCT05093023 - ABCB1 SNPs as Predictors of PIPN
Completed NCT05410548 - Comorbidity Screening and Referral by Prosthetists N/A
Completed NCT03021174 - Exercise and Nutrition Interventions During Chemotherapy N/A
Not yet recruiting NCT06422949 - Efficacy and Safety of HILOTERM® Device for the Prevention of Peripheral Neuropathy N/A
Terminated NCT03777956 - The Effect of Lacosamide in Peripheral Neuropathic Pain Phase 2
Terminated NCT04218448 - Evaluation of the Interest of Hypno-relaxation During Somatosensory Evoked Potentials N/A