Neuromuscular Blockade Clinical Trial
Official title:
The Use of Neuromuscular Blockade Monitor as a Strategy for Neuromuscular Blockade Agents Saving in ICU COVID-19 Patients
This is a retrospective case-controlled study of the effect of the use of a neuromuscular
blockade (NMB) monitor on the consumption of NMB agents in patients under mechanical
ventilation in the context of COVID-19.
The use of NMB agents during mechanical ventilation in patients with acute respiratory
distress syndrome (ARDS) improves respiratory support conditions and reduces mortality. In
the context of COVID-19 pandemic, patients with severe forms of the disease hospitalized in
intensive care units (ICU) benefit from prolonged mechanical ventilation with frequent use of
NMB agents. Large amount of such patient admitted in a short time has led to a shortage of
NMB agents, particularly cisatracurium.
The use of NMB monitors (for example - Train of Four (TOF)) is a well-established practice in
general anesthesia. There is no recommendation for the use of NMB monitor in ICU patients
available up to date. However, in the attempt to reduce the consumption of NMB agents a NMB
monitoring was used in ICU patients during the COVID-19 pandemic at university hospitals of
Hospices Civil de Lyon, with the endorsement of the local College of Anesthetists.
The aim of our study is to evaluate if the use of a NMB monitor decreases the consumption of
NMB agents in patients under mechanical ventilation in the context of COVID-19.
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