Neuromuscular Blockade Clinical Trial
Official title:
Magnesium Sulfate Effect Following the Reversal of Neuromuscular Blockade Induced by Rocuronium With Sugammadex
The aim of this study is to evaluate the treatment effect of magnesium sulfate on the T4 / T1 ratio after reversal with sugammadex deep or moderate neuromuscular blockade induced by rocuronium.
Sugammadex is a novel neuromuscular blocking reversal agent. Its mechanism of action is the
encapsulation of rocuronium and vecuronium molecules. Numerous studies show a potential role
of magnesium in reducing anesthetic requirements, sympathetic response to surgical trauma,
antinociceptive action and neuroprotective effects. However, its use is limited because
magnesium potentiates non-depolarizing neuromuscular blocking agents.
Primary outcome: evaluating the effect of treatment with magnesium sulfate the T4 / T1 ratio
after reversal with sugammadex deep and moderate neuromuscular blockade induced by
rocuronium.
Secondary outcome: evaluate the occurrence of severe respiratory events, the incidence of
residual neuromuscular block in the post-anesthetic recovery room, evolution of T1 high, and
postoperative pain.
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