Reversal of Neuromuscular Blockade During the General Anaesthesia

Neuromuscular Blockade Clinical Trial

Official title: Reversal of Neuromuscular Blockade During the General Anaesthesia

Status Recruiting

Clinical Trial Summary

There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients starts to relax spontaneously again after the tof ratio has already recovered to the safe level (>90%).

The mechanism behind this in not well understood, and the incidence of the phenomenon is unclear. In this study the investigators try to determine the incidence of the aforementioned postrecovery relaxation.

Clinical Trial Description

There are individual reports indicating that after the reversal of nondepolarizing neuromuscular blockade with neostigmine, some patients start to relax spontaneously again after the tof ratio has already recovered to the safe level (90%). The mechanism behind this in not well understood and the incidence of the phenomenon is unclear.

The aim of this study is to monitor the reversal of rocuronium induced neuromuscular blockade with neostigmine. The neuromuscular blockade is monitored with train of four stimulations using electromyography. After the reversal agent is given and train of four ratio has recovered to the level of 90%, the neuromuscular blockade is monitored another 30min to see if tof ratio starts to spontaneously fall again under the 90%. If aforementioned postrecovery relaxation happens, the investigators are able to calculate the incidence of the phenomenon. ;

Related Conditions & MeSH terms

• Neuromuscular Blockade

• NCT number: NCT04048655
• Study type: Interventional
• Source: Tampere University Hospital
• Contact: Jarno Salminen, Licenciate
• Phone: +358503480709
• Email: jarno.salminen@fimnet.fi
• Status: Recruiting
• Phase: N/A
• Start date: April 8, 2020
• Completion date: December 31, 2025