Neuromuscular Blockade Clinical Trial
Official title:
Prediction of the Recovery of Neuromuscular Transmission After Curarization, Pilot Study
The vast majority of patients receive neuromuscular blockers during surgical procedures,
either as a single injection to facilitate intubation or as repeated injections to induce
muscle relaxation necessary for surgery. The action of neuromuscular blockers is monitored by
measuring the contraction force of the adductor of the thumb after stimulation of the ulnar
nerve.Different types of stimulation, such as train-of-four (TOF), post- Tetanus count (PTC),
double-burst stimulation (DBS) measure different degrees of curarization.The duration of
action of neuromuscular blockers has significant interindividual variability. If the
investigators know how to measure the degree of curarization of a patient at a given time, it
is difficult to know how long it will take to recover neuromuscular function.
The purpose of this study is to determine if the individual recovery of a patient can be
predicted form data obtained at the beginning of his/her recovery curve. The investigators
propose to record all neuromuscular transmission monitoring data in 100 patients. From these
data, the investigators will try to develop an algorithm that would extrapolate the recovery
curve of an isolated patient from the fist neuromuscular monitoring data.
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