Neuromuscular Blockade Clinical Trial
Official title:
Effect of Magnesium Sulfate on the Reversal of Neuromuscular Blockade With Sugammadex: a Prospective, Randomized Double-blind Trial
The aim of this study is to determine the recovery time of moderate neuromuscular blockade with sugammadex in adults pretreated with magnesium sulfate.
Sugammadex is a novel neuromuscular blocking reversal agent. Its mechanism of action is the
encapsulation of rocuronium and vecuronium molecules. Numerous studies show a potential role
of magnesium in reducing anesthetic requirements, sympathetic response to surgical trauma,
antinociceptive action and neuroprotective effects. However, its use is limited because
magnesium potentiates non-depolarizing neuromuscular blocking agents.
Primary outcome: evaluate the effect of pretreatment with magnesium sulfate on the time
reversal with sugammadex (recovery of the T4/T1 ratio = 0.9) of moderate neuromuscular
blockade (two answers to a train-of-four TOF) induced by rocuronium.
Secondary outcome: evaluate severe respiratory events, the incidence of residual
neuromuscular blockade in the post anesthesia recovery room and postoperative pain.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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