Chart Review: Central Motor Conduction Time in Neurological Disorders

Status Completed

Clinical Trial Summary

Background:

TMS stands for transcranial magnetic stimulation. It is a non-invasive way to stimulate the brain. It helps researchers study the nervous system. TMS can assess central motor conduction time (CMCT). That can be used to diagnose some diseases. It can also show how well treatments are working. Researchers want to study the records of people who have already had TMS. They want to see how it relates to the results of diagnostic studies.

Objectives:

To study the results of transcranial magnetic stimulation in certain neurological disorders. To create a descriptive analysis of the results.

Eligibility:

Records that are already in the NINDS database

Design:

The study will not enroll any participants.

Researchers will search the database for certain terms. These include TMS, CMTC, and motor evoked potentials. This will identify records of people who had TMS for diagnosis.

Using data from the records, researchers will calculate CMCT. They will note other data that relate to CMCT.

Researchers will analyze their findings. They will write a review article.

Personal data will be removed from all the records before the findings are analyzed.

Clinical Trial Description

Objective- To retrospectively study the results of transcranial magnetic stimulation (TMS) in various neurological disorders and create a descriptive analysis of the results.

Study population- Existing records of patients within the NINDS database who have had TMS performed to measure central motor conduction time (CMCT).

Design-

- Retrospective descriptive analysis.

- The NINDS EMG Database will be queried using terms such as TMS, CMCT, and MEP (motor evoked potentials) to identify EMG reports on patients who underwent TMS for diagnosis

- Within these reports peripheral motor conduction time (PMCT), the cortical motor evoked potential (MEP) latency and amplitude will be used to calculate CMCT, clinical patient factors pertinent to estimation of CMCT as well clinically significant physical exam findings will be recorded as well.

- Clinical diagnoses and neurological exams will be extracted from medical records

- Patient identifiers will be de-linked after compiling data from medical records

Outcome measures

- Results of CMCT using TMS in different diagnoses will be summarized for different neurologic disorders and correlated to clinical exam measures documented in previous records ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03300856
Study type	Observational
Source	National Institutes of Health Clinical Center (CC)
Contact
Status	Completed
Phase
Start date	October 4, 2017
Completion date	July 19, 2018

View Details

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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.