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Neurological Disorder clinical trials

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NCT ID: NCT06390800 Completed - Clinical trials for Neurological Disorder

Personalized Motor Learning in Primary Care Physiotherapy (TREAT)

Start date: September 6, 2023
Phase:
Study type: Observational

Over the last decade many scientific articles have been published on motor learning in neurological and geriatric rehabilitation. To make the available findings comprehendible and clear for physiotherapists, a card set and website have been developed. The aim of this prospective study is to evaluate the use and experiences of the card set and website designed to aid the physiotherapist in decision making with regards to motor learning. The following research question is central to this evaluation: How are the developed card set and website used and experienced by physiotherapists in primary care during the treatment of patients with neurological or geriatric conditions?

NCT ID: NCT06278025 Completed - Dysphagia Clinical Trials

Dysphagia and Deep Cervical Flexor Muscles

Start date: September 1, 2019
Phase:
Study type: Observational [Patient Registry]

Cervical posture is vital for normal swallowing function. Changes in cervical posture during swallowing alter the bolus flow and swallowing kinematics through changes in gravity and oropharyngeal space. The hyoid bone does not articulate with any bone, so it requires adequate tension of the hyolaryngeal complex and proper cervical postural alignment to maintain its stabilization and position. Changes in cervical posture and stabilization can cause changes in hyoid bone position and kinematics through muscles and ligaments which may lead to decrease in hyoid elevation, loss of optimal strength of the suprahyoid and infrahyoid muscles due to disrupted length-tension relationship, and an increased risk of aspiration due to insufficient laryngeal elevation. Further, deterioration in cervical posture and decreased stabilization resulting from cervical muscle weakness or/both endurance could affect the control and strength of masticatory muscles, tongue muscles and suprahyoid - infrahyoid muscles, which are involved in swallowing function. Whereby DCF weakness gives rise to inadequate cervical stabilization, change in hyoid bone stabilization, alterations in suprahyoid and infrahyoid muscle function, and decreased laryngeal elevation may adversely affect the normal function of the swallowing related muscles. Thus, decreased cervical stabilization, which is often seen in neurological diseases, may be related to neurogenic dysphagia. Given the known changes in cervical stabilization as a consequence of neurologic injury, the additional impact on swallowing or a potentially already neurologically-disordered swallow is considered. Thus, loss of cervical stabilization may be one of the factors affecting dysphagia in patients with neurological diseases providing more information on all potential factors contributing to swallow impairment, potentially leading to more targeted and effective swallowing interventions. However, there is no study investigating the role of the DCF muscles in dysphagia. Therefore, the aim of the present study was to comparison of deep cervical flexor muscle strength and endurance in patients with and without neurogenic dysphagia.

NCT ID: NCT05938452 Completed - Clinical trials for Neurological Disorder

Safety and Tolerability of Glyceryl Tribenzoate (GTB) Capsules in Healthy Subjects

Start date: December 12, 2022
Phase: Phase 1
Study type: Interventional

This study is designed to assess the safety and PK/PD of GTB and Benzoic Acid (Benzoate) using a single ascending dose (SAD) study (under fasting conditions).

NCT ID: NCT05822557 Completed - Stroke Clinical Trials

Bolus Pouch Feed Study

Start date: April 1, 2023
Phase: N/A
Study type: Interventional

The primary aim of this study is to evaluate the impact of introducing a new enteral tube feed on health and feeding related quality of life. Secondary aims are to assess ease of use, liking, compliance, gastrointestinal tolerance, nutrient intake, anthropometric changes and safety.

NCT ID: NCT05459779 Completed - Clinical trials for Neurological Disorder

Evaluation of a Robotic Assistance Module Against Positive and Negative Obstacles for Driving Electric Wheelchair

SWADAPT 3
Start date: July 8, 2022
Phase: N/A
Study type: Interventional

The device that is the subject of this investigation is a robotic assistance module for driving a semi-autonomous electric wheelchair. This module is designed to accessorize the electric wheelchair to improve the safety conditions when driving an electric wheelchair, which on the one hand reduces the accident rate of wheelchair and on the other hand and facilitates the access to the wheelchair to people who cannot claim it without the use of a safety device of this type. The robotic assistance module is programmed to detect positive and negative obstacles.

NCT ID: NCT05350839 Completed - Clinical trials for Musculoskeletal Pain

Reliability and Validity of HHIRS General Quality of Life Questionnaire

HHIRS-GQOL
Start date: March 20, 2021
Phase:
Study type: Observational [Patient Registry]

Quality of life is conceded by copious musculoskeletal and neurogenic conditions which are evaluated by manifold questionnaires. These questionnaires are obtainable in English and many other languages but in Pakistan, these cannot be applied due to differences in languages, lifestyles, culture, and activities of daily living (ADL's). In relation to the culture of Pakistan, there are many accomplishments such as offer prayers and other domestic obligation which cannot be executed appropriately if any Musculoskeletal and neurogenic disorders are existing. All these disorders can be assessed appropriately by questionnaires previously accessible but not in a single tool.

NCT ID: NCT05230849 Completed - Clinical trials for Neurological Disorder

Effectiveness of a Treatment Plan of Neurological Physiotherapy in Conjunction With Ultrasound-guided Ultrasound-guided Dry Needling in Stroke Patients.

Start date: February 12, 2022
Phase: N/A
Study type: Interventional

The aim of the study is to assess the efficacy of dry needling in stroke patients in combination with intensive neurological physiotherapy. together with intensive neurological physiotherapy treatment. Randomised and blinded experimental study control group where the sample recruited was 20 patients, who were randomly assigned to a control group. randomly assigned to a control group, where they received intensive treatment, or to an intervention group, where they received intervention group, where they received ultrasound-guided dry needling of the tibialis anterior and posterior muscles followed by an intensive followed by intensive neurological physiotherapy treatment.

NCT ID: NCT05097066 Completed - Surgery Clinical Trials

Patterns and Outcomes of Neurosurgery in England Over a Five-year Period

Start date: April 1, 2013
Phase:
Study type: Observational

Neurosurgical practice has seen many important changes over several decades with advances in treatments and the types of patients treated. Neurosurgical procedures have evolved, and as outcomes have improved the number of patients being treated has increased. There are no recent evaluations of national neurosurgical practice in the United Kingdom (UK), with the last prospective cohort studies being Safe Neurosurgery 1993 and Safe Neurosurgery 2000. More recent studies of neurosurgical services have been based on data from single institutions or surgeons and these may not give a representative picture of practice nationally. Recent national quality improvement programmes for neurosurgery in England (such as the National Neurosurgical Audit Programme (NNAP) and Cranial Neurosurgery and Spinal Surgery Getting It Right First Time (GIRFT) Programmes) have focused on using national hospital administrative datasets. To be effective, quality improvement initiatives require robust outcome measures and quality (process) indicators. Currently, there is a lack of validated quality indicators for neurosurgery, with practice often being described using generic measures such as readmission and reoperation rates and length of stay. Many studies have been able to derive these common outcome measures, but it may also be possible to produce indicators specific to neurosurgery. The aim of this observational study was firstly to describe the current pattern of neurosurgical admissions and procedures in England, and thereby given an overview of the epidemiology of neurosurgical patients. Secondly, it aims to investigate the range of outcome measures that might be produced from hospital administrative data and use these to assess the quality of care in neurosurgery.

NCT ID: NCT04934085 Completed - Covid19 Clinical Trials

COVID-19 Versus Neurological Impairment, Physical Activity, Social Contacts and Education

Start date: June 30, 2021
Phase:
Study type: Observational

The research will make it possible to assess patients who recovered from COVID-19 for the incidence of neurological problems (impaired balance, gait, coordination, concentration and attention), and changes in the quality of life, physical activity, social contacts and education.

NCT ID: NCT04820153 Completed - Clinical trials for Neurological Disorder

Monitoring Physical Activity in Hispanic Women With Chronic Neurological Disorders

Start date: March 26, 2019
Phase: N/A
Study type: Interventional

The primary goal of this proposal is to demonstrate the feasibility of using a Fitbit charge to monitor and promote physical activity in a diverse population of Hispanic women with chronic neurological disorders. Hispanic women will also receive behavioral coaching using a Lifestyle Redesign approach to enhance physical activity in their daily lives. The secondary goal of this proposal is to investigate whether changes in physical activity are associated with (i) quality of life including perception of health and well- being and (ii) frequency of hospital and county clinic visits.