Clinical Trials Logo

Clinical Trial Summary

The prevalence and typical patterns of neurological complications in hospitalized COVID-19 patients admitted to the intensive care units of the University Hospital Zurich will be investigated. The impact of neurological complications among COVID-19 patients on mortality, functional outcome, and organizational outcomes will be analyzed.


Clinical Trial Description

This study is a prospective observational cohort study to document prevalence and severity of neurological symptoms among patients requiring critical care admission for confirmed novel coronavirus disease (COVID-19). COVID-19 is classified as severe acute respiratory syndrome 2 (SARS-CoV-2) and shares significant structural and biological similarities with SARS-CoV, which has neuroinvasive properties and brainstem involvement. Early reports of COVID-19 progression indicate presence of severe neurological complications, including seizures, coma, encephalitis, and cerebrovascular events including ischemic stroke, intracranial hemorrhage, and cerebral venous sinus thromboses. In addition, recent data from Zika-virus and H1N1 influenza pandemics reveal a high incidence of neurological complications, including Guillain Barré syndrome and neonatal microcephaly for Zika-virus and narcolepsy with H1N1 infections. Early reports from China suggest neurological symptoms may occur in approximately 36% of SARS-CoV-2 positive patients, with increased prevalence among more severe cases, and fall into three categories: central nervous system symptoms or diseases, peripheral nervous system symptoms, and skeletal muscular symptoms. However, the exact prevalence of these conditions and impact on patient disease severity and outcomes is unknown. As the incidence and severity of COVID-19 infection continues to rapidly rise on an international level, it is imperative to capture prospective data to accurately document prevalence, severity and clinical characterization of neurological components of COVID-19, the influence of treatment regimens of neurological complications, and role of these confounders on patient and organizational outcomes. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04418609
Study type Observational
Source University of Zurich
Contact
Status Completed
Phase
Start date May 1, 2020
Completion date June 9, 2022

See also
  Status Clinical Trial Phase
Recruiting NCT03866876 - Eucapnic pH Compared With Arterial pH and Base Deficit
Active, not recruiting NCT04070131 - Horse Assisted Rehabilitation Postoncologic Treatment in Children and Adolescents: Physical and Psychological Effects N/A
Completed NCT06068673 - The Potential Impact of Clindamycin on Neurosurgery Patients. N/A
Not yet recruiting NCT04158024 - Erector Spinae Plane Block in Congenital Heart Disease Patients N/A
Completed NCT04188717 - Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation
Completed NCT04387513 - Impact of Early Cardiac Surgery in Severe Left Endocarditis With Neurological Complications: a Retrospective Study