Neurogenic Orthostatic Hypotension Clinical Trial
Official title:
Evaluation of Efficacy and Tolerance of Fludrocortisone (Flucortac) in the Treatment of Orthostatic Neurogenic Hypotension
To evaluate the efficacy of a 4-week fludrocortisone (FLU) treatment on systolic blood pressure depression after 5 minutes of active orthostatism in patients with neurogenic orthostatic hypotension (HON) symptomatic, despite treatment with non-drug measures with or without midodrine.
The objective of the study is to demonstrate the efficacy of FLU on systolic blood pressure depression in patients with neurogenic orthostatic hypotension. The study is randomised versus placebo.Each patient will be followed for a maximum of 5 months, with no more than 8 visits to the investigator (V0 at Day-7, V1 at D0, V2 at D7, V3 at D+14, V4 at D+21, V5 at D+ 28, V6 at D+56 and V7 only for patients on the FLU arm at D+140. The presence of a comparator control group with placebo permits to evaluate the efficacy and the tolerance of FLU independently of the natural evolution of the pathology, in patients benefiting from a non-drug or possibly medicated treatment (midodrine) but insufficient. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02705755 -
TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)
|
Phase 2 | |
| Recruiting |
NCT04620382 -
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients
|
Early Phase 1 | |
| Recruiting |
NCT05908760 -
CO2 Rebreathing in nOH: A Proof-of-Concept Pilot Study
|
N/A | |
| Recruiting |
NCT05295810 -
Hypercapnia in Orthostatic Hypotension
|
N/A | |
| Recruiting |
NCT05489575 -
CPAP for the Treatment of Supine Hypertension
|
N/A | |
| Recruiting |
NCT01799915 -
Natural History Study of Synucleinopathies
|
||
| Terminated |
NCT00977171 -
Study To Assess The Clinical Benefit Of Droxidopa In Subjects With Chronic Fatigue Syndrome
|
Phase 2 | |
| Completed |
NCT01132326 -
Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304)
|
Phase 3 | |
| Completed |
NCT00738062 -
Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
|
Phase 3 | |
| Withdrawn |
NCT04976101 -
Sinusoidal Galvanic Vestibular Stimulation for Neurogenic Orthostatic Hypotension / Syncope
|
N/A | |
| Completed |
NCT03350659 -
Efficacy and Safety of Midodrine and Atomoxetine for Neurogenic OH
|
Phase 4 | |
| Completed |
NCT02784535 -
Norepinephrine Transporter Blockade, Autonomic Failure (NETAF)
|
Phase 2 | |
| Completed |
NCT03229174 -
Brain Perfusion & Oxygenation in Parkinson's Disease With NOH
|
Phase 4 |