Clinical Trials Logo

Clinical Trial Summary

This is a Phase 2, open-label, multi-centre study of surufatinib in patients with low to intermediate grade (Grade 1 or Grade 2), well-differentiated neuroendocrine tumours (NETs).


Clinical Trial Description

This is a Phase 2, open-label, multi-centre study of surufatinib in patients with low- to intermediate-grade (Grade 1 or Grade 2), well-differentiated NETs. The study will enroll 4 cohorts of varying NETs, as follows: - Cohort A - NET of lung origin - Cohort B - NET of small bowel origin - Cohort C - NET of non-small bowel, non-pancreas, and non-lung origin - Cohort D - NET of any origin (DDI substudy) All patients will be treated with oral surufatinib 300 mg QD in treatment cycles of 28 days starting on Cycle 1 Day 1. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04579679
Study type Interventional
Source Hutchmed
Contact
Status Active, not recruiting
Phase Phase 2
Start date August 13, 2021
Completion date September 15, 2024

See also
  Status Clinical Trial Phase
Terminated NCT00323076 - [18]F-FAZA PET Imaging Study in Patients With Cancer of the Head & Neck, Lung, Renal Cell, Brain, Lymphoma and Neuroendocrine Tumours Phase 1/Phase 2
Completed NCT02075606 - Circulating Tumour Cells in Somatuline Autogel Treated NeuroEndocrine Tumours Patients Phase 4
Completed NCT00326469 - Efficacy and Safety of Lanreotide Autogel in Tumour Stabilization of Patients With Progressive Neuroendocrine Tumours Phase 2
Terminated NCT02788578 - A Retrospective Data Analysis of Therapy With PRRT Combined With Lanreotide Autogel® for Neuroendocrine Tumours
Completed NCT01840449 - Somatuline Predictive Factors in Acromegaly and NET
Completed NCT02698410 - Efficacy and Safety of Lanreotide Autogel (ATG) in Combination With Temozolomide in Subjects With Thoracic Neuroendocrine Tumors. Phase 2
Active, not recruiting NCT02923934 - A Phase II Trial of Ipilimumab and Nivolumab for the Treatment of Rare Cancers Phase 2
Completed NCT01673906 - 68-Ga-labeled Octreotide Analogues PET in Duodenal-pancreatic Neuroendocrine Tumours Phase 2