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Early Identification of Cardiac Involvement in Patients With Carcinoid: Clinical and Prognostic Implications

Neuroendocrine Tumors Clinical Trial

Official title:
Early Identification of Cardiac Involvement in Patients With Carcinoid: Clinical and Prognostic Implications

Clinical Trial Summary

This study is for patients with neuroendocrine tumours (NET) with or without carcinoid syndrome followed by NET Unit of European Institute of Oncology. The objective of the trial is to evaluate biochemical markers of myocardial injury (high-sensitive troponins), haemodyinamic markers (pro-brain natriuretic peptide (BNP), N-terminal (NT)-BNP (NT-proBNP)), and markers of fibrosis (Suppression of Tumorigenicity 2 (ST2) in patients with neuroendocrine tumours (NET) with or without carcinoid syndrome.

Clinical Trial Description

The main aim of this study is to evaluate blood levels of biomarkers of cardiac damage (ultra-sensitive troponin I), hemodynamic impairment (BNP, NT-proBNP), and cardiac fibrosis (ST2) in patients with diagnosed neuroendocrine tumours (NET) with or without carcinoid syndrome The secondary objective is to correlate the levels of the above markers with the presence/entity of cardiac involvement and its progression over time. All patients will undergo: - a baseline assessment including: - blood sampling for US-Troponin I, BNP, NT-proBNP, ST2 - cardiological evaluation including ECG and echocardiogram - a three-monthly revaluation of these markers - a six monthly cardiological reassessment with a echocardiogram ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06321692
Study type Interventional
Source European Institute of Oncology
Contact Daniela Cardinale, MD
Phone +39 0257489748
Email daniela.cardinale@ieo.it
Status Recruiting
Phase N/A
Start date October 9, 2019
Completion date December 31, 2024
View Details
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