Telotristat With Lutathera in Neuroendocrine Tumors

Status Terminated

Clinical Trial Summary

This trial will test the hypothesis that Telotristat treatment increases the antitumor efficacy of Lutetium Lu 177 Dotatate therapy in neuroendocrine tumors (NETs).

Clinical Trial Description

Neuroendocrine tumors (NETs) are a very heterogeneous group of tumors that develop predominantly in the gastrointestinal and pulmonary systems. Clinical detection and diagnosis are more reliable at late stages when metastatic spread has occurred. Patients with advanced disease may suffer from complications of uncontrolled hormone secretion and usually succumb due to tumor progression. This trial tests the hypothesis that inhibition of serotonin production with Telotristat will lead to cytostatic effects on neuroendocrine tumors and will complement the anti-tumor activity of Lutetium 177 Dotatate. The proposed combination may result in improved treatment efficacy as reflected by improved 20-month progression-free survival (PFS) as compared to historical control. ;

Study Design

Related Conditions & MeSH terms

Neuroendocrine Tumors

Clinical Trial Details

NCT number	NCT04543955
Study type	Interventional
Source	University of Kentucky
Contact
Status	Terminated
Phase	Phase 2
Start date	September 13, 2021
Completion date	June 3, 2022

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