Neuroendocrine Tumors Clinical Trial
Official title:
Best Therapy for Patients With Neuroendocrine Tumors
A prospective observational study containing three arms comprising different therapeutic measures to treat patients with neuroendocrine tumors in advanced stages. The therapy arms include local ablative therapy such as TACE or SIRT, surgery and RFA with peptide receptor radiotherapy.
Study design:
Prospective observational study comparing ablative measures as TACE or SIRT with surgery/RFA
and with peptide receptor radio-therapy in patients with advanced well-differentiated
neuroendocrine tumors with lymph node or distant metastases (N1, M1) Prospective evaluation
Primary end points: time to progression Secondary end points: survival, quality of life
(EORTC-QLQ30), weight, time of hospitalization, Karnofsky index) Non-randomized cohort study
Number of patients needed in all groups: 70 per group, 210 overall Evaluation of response to
therapy every 3-6 months by imaging, clinical status, weight, quality of life,
Karnofsky-index Cross-over allowed if therapy changes
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