Neuroendocrine Tumors Clinical Trial
Official title:
A Phase II Study of Bevacizumab in Combination With Temozolomide in Patients With Advanced Neuroendocrine Tumors
The purpose of this study is to determine what effects (good and bad) bevacizumab and temozolomide have on patients with neuroendocrine tumors.
Patients will receive temozolomide orally once daily for one week, followed by a one-week
rest period. This one-week on/one week off schedule will continue for the duration of
treatment unless significant side effects develop.
Bevacizumab will be administered intravenously every other week. After eight weeks (two
cycles), a CT scan will be performed to see how treatment affected tumor growth.
Bactrim, an antibiotic, and acyclovir, an antiviral medicine, will be given in order to help
prevent infection.
Blood tests will be done every other week to evaluate any side effects.
Once the study has been completed, a physical exam, vital signs, blood tests, and CT scan
will be performed.
Patients will remain on the study as long as they continue to receive benefit from the
treatment and there are no serious side effects.
;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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