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A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury

Infant Development Clinical Trial

Official title:
A Safety and Feasibility Trial Protocol of Metformin in Infants After Perinatal Brain Injury

Clinical Trial Summary

Infants with hypoxic-ischemic encephalopathy (HIE) are at high risk for neurodevelopmental impairment, despite current standards of care. Adjunctive treatments to promote brain repair are needed. The antidiabetic drug metformin has recently been recognized as a neurorestorative agent, but, to date, has not been used in infants. Herein, the investigator describes a clinical trial with the aim of demonstrating the safety and feasibility of metformin use to improve neurodevelopmental outcomes in infants with HIE.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06429007
Study type Interventional
Source Boston Children's Hospital
Contact Vanessa Young, MS, RN
Phone 617-355-8330
Email Vanessa.young@childrens.harvard.edu
Status Not yet recruiting
Phase Phase 2
Start date October 1, 2024
Completion date October 1, 2027
View Details
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