Parkinson's Disease Clinical Trial
Official title:
NMDA Receptor Antagonist Treatment of Neurodegenerative Disease
This study is designed to determine whether dextromethorphan, a drug commonly found in cough
medicine, is beneficial and safe for the treatment of Parkinson's disease and other diseases
that might share biochemical abnormalities with Parkinson's disease.
Patients with Parkinson's disease are missing the chemical neurotransmitter dopamine. This
occurs as a result of destructive changes in an area of the brain responsible for making
dopamine, the basal ganglia. Rhythmical muscular tremors, rigidity of movement, shuffling
footsteps, droopy posture, and a mask-like expression on the face characterize Parkinson's
disease.
Researchers believe that dextromethorphan may be able to safely modify psychomotor function
of patients with Parkinson's Disease.
The ability of the putative excitatory amino acid receptor antagonist, dextromethorphan, to modify psychomotor function safely in patients with neurodegenerative disease will be evaluated using a modified double-blind placebo-controlled design. Therapeutic activity will be rated at various doses by means of standard motor and cognitive performance scales. Safety will be assessed at frequent intervals by clinical observation and laboratory tests. ;
Endpoint Classification: Safety/Efficacy Study, Primary Purpose: Treatment
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