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Nervous System Neoplasms clinical trials

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NCT ID: NCT01180881 Active, not recruiting - Brain Tumor Clinical Trials

Neurobehavioral Functioning in Pediatric Brain Tumor Patients After Proton Beam Radiation Treatment

Start date: October 2009
Phase:
Study type: Observational

The aim of this study is to follow up with all of the pediatric brain tumor patients who received proton beam radiation therapy at Massachusetts General Hospital (MGH) for which there is baseline neuropsychological testing in order to measure changes, if any, in neurobehavioral functioning (executive skills, emotional/behavioral functioning, and adaptive abilities) and their use of special education services at one year or more post-treatment. The investigators will also correlate neurobehavioral data with pertinent clinical information. Participation will be maximized through the use of mail-in, parental- and self-report questionnaires.

NCT ID: NCT01172912 Recruiting - Clinical trials for Brain and Central Nervous System Tumors

High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy

Start date: October 2010
Phase: Phase 2
Study type: Interventional

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. An autologous stem cell transplant may be able to replace blood-forming cells that were destroyed by chemotherapy. PURPOSE: This phase II trial is studying the side effects of giving high-dose chemotherapy together with stem cell transplant and to see how well it works in treating patients with metastatic germ cell tumors that have not responded to first-line therapy.

NCT ID: NCT01164189 Completed - Clinical trials for Central Nervous System Tumors

Bevacizumab in Recurrent Grade II and III Glioma

TAVAREC
Start date: February 2011
Phase: Phase 2
Study type: Interventional

RATIONALE: Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet known whether temozolomide is more effective when given with or without bevacizumab in treating patients with recurrent glioma. PURPOSE: This randomized clinical trial is studying how well temozolomide works with or without bevacizumab in treating patients with recurrent glioma.

NCT ID: NCT01163539 Terminated - Bone Cancer Clinical Trials

Cyberknife Radiosurgery and Quality of Life

Start date: July 2010
Phase: N/A
Study type: Observational

The purpose of this study is to look at pain control and QOL improvement after treatment with CK Radiosurgery for spinal metastases.

NCT ID: NCT01158300 Completed - Clinical trials for Brain and Central Nervous System Tumors

PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors

Start date: November 2010
Phase: Phase 1
Study type: Interventional

RATIONALE: PTC299 may stop the growth of tumor cells by blocking blood flow to the tumor. PURPOSE: This phase I trial is studying the side effects and the best dose of PTC299 in treating young patients with recurrent or refractory primary central nervous system tumors.

NCT ID: NCT01135563 Completed - Solid Tumors Clinical Trials

Study of Vinblastine and Sirolimus in Children With Recurrent/Refractory Solid Tumours Including CNS Tumours

Start date: April 2010
Phase: Phase 1
Study type: Interventional

This study is a Phase I study using vinblastine and sirolimus in patients with relapsed solid tumors including selected brain tumors and lymphoma. The investigators hypothesis is that the combination administration of weekly vinblastine and sirolimus is safe.

NCT ID: NCT01067196 Completed - Clinical trials for Central Nervous System Tumors

Outcomes Study of Late Effects After Proton RT for Pediatric Tumors of the Brain, Head, and Neck

CN01
Start date: February 2010
Phase:
Study type: Observational

The purpose of this study is to collect information from medical records to see what effects proton beam radiation has on cancer and analyze possible side effects.

NCT ID: NCT01062399 Completed - Clinical trials for Brain and Central Nervous System Tumors

Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

RTOG 0913
Start date: December 2010
Phase: Phase 1/Phase 2
Study type: Interventional

RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Radiation therapy uses high energy x-rays to kill tumor cells. Giving everolimus together with temozolomide and radiation therapy may kill more tumor cells. PURPOSE: This phase I/II trial is studying the side effects and best dose of everolimus when given together with temozolomide and radiation therapy and to see how well it works in treating patients with newly diagnosed glioblastoma multiforme.

NCT ID: NCT01052363 Withdrawn - Clinical trials for Central Nervous System Tumors

OXC401-PO1s/WVU 1309 - A Pilot Study of Fosbretabulin With Bevacizumab in Recurrent High-Grade Gliomas

Start date: January 2010
Phase: Phase 1
Study type: Interventional

Pilot Trial of CA4P with Avastin in Recurrent Gliomas

NCT ID: NCT01032200 Completed - Fatigue Clinical Trials

Armodafinil in Treating Fatigue Caused By Radiation Therapy in Patients With Primary Brain Tumors

Start date: August 1, 2010
Phase: Phase 2
Study type: Interventional

RATIONALE: Armodafinil may help relieve fatigue and improve quality of life in patients with cancer receiving radiation therapy to the brain. PURPOSE: This clinical trial is studying how well armodafinil works in treating fatigue caused by radiation therapy in patients with primary brain tumors.