Healthy Clinical Trial
Official title:
Functional and Metabolic Imaging Using Magnetic Resonance Imaging and Spectroscopy
Technical advances in magnetic resonance imaging (MRI) and magnetic resonance spectroscopy
(MRS) have provided researchers with the opportunity to study changes of the central nervous
system (CNS) and improve diagnosis and therapy of CNS disease. New MRI and MRS techniques
specifically designed for functional MRI (fMRI) and MRS imaging of the CNS will be evaluated
in normal volunteers and in patients with CNS diseases. This study will develop and evaluate
new magnetic resonance pulse sequences for performing MRI or MRS and compare the results to
existing MR techniques.
Patients and volunteers age 18 and older are eligible for the study. A history will be taken
in which exclusion criteria (such as having a pacemaker or cochlear implants) will be
addressed, and a pregnancy test will be administered to women of childbearing age. Each
subject will also be asked to fill out a questionnaire.
Study participants will lie in the MRI scanner from 20 minutes to 2 hours. A coil may be
placed on the head and participants may be asked to do simple or complex tasks. A catheter
will be placed in an arm vein and a contrast agent will be administered. This agent will
allow structures in the brain to show up more clearly.
Technical advances in Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) have provided researchers with the opportunity to study functional and metabolic changes of the central nervous system (CNS) in both normal individuals and individuals with neurological diseases in response to sensory, motor or cognitive stimulation. New MRI and MRS techniques specifically designed for Functional Magnetic Resonance Imaging (fMRI) and Magnetic Resonance Spectroscopic Imaging of the CNS will be evaluated at 1.5 and/or at 4.0 Tesla on normal volunteers and in patients with CNS pathology. ;
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