Nerve Injury Clinical Trial
— facial nerveOfficial title:
Histopathological, Biochemical And Electrophysiological Evaluation Of Single Or Combined Use Of Diode Laser/Steroid Treatment On Facial Nerve Injury
Verified date | December 2023 |
Source | Recep Tayyip Erdogan University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The objective of the study will be to investigate the effect of low-level diode laser therapy (LLLT) and steroid on facial nerve injury. Thirty five male Wistar rat will randomly be divided into five groups: healthy control (HCG); damage control (DC); laser (LG); steroid (SG); and combined laser and steroid group (LSG). Right facial nerve electromyography (EMG) data will record after facial nerve damage done and before sacrification at 4th week.The results will be evaluated histopathologically, electrophysiologically and biochemically.
Status | Active, not recruiting |
Enrollment | 35 |
Est. completion date | February 1, 2024 |
Est. primary completion date | June 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 4 Months to 6 Months |
Eligibility | Inclusion Criteria: -Thirty-five male Sprague-Dawley rats weighing 200-300 g will be included the study Exclusion Criteria: -Rats that are older than 6 months and are not healthy and have impaired facial motor functions will be excluded from the study. |
Country | Name | City | State |
---|---|---|---|
Turkey | RTEU Faculty of Dentistry | Rize |
Lead Sponsor | Collaborator |
---|---|
Recep Tayyip Erdogan University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Electromyographic Analysis | Measuring the amplitude and latency of the action potential occurring in the nerve with electromyography(On facial nerve) | 1 month | |
Secondary | Biochemical Analysis | Determination of MDA and GSH levels in blood samples taken | 1 month |
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