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Nephrology clinical trials

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NCT ID: NCT06441435 Not yet recruiting - Nephrology Clinical Trials

The Effect of AC-134 in Chronic Kidney Diseases

Start date: May 24, 2024
Phase: N/A
Study type: Interventional

The objective is to explore the effects of adding AC-134 on renal function, proteinuria, uremic toxins, and metabolism-related markers in chronic kidney disease.

NCT ID: NCT05991245 Recruiting - Acute Kidney Injury Clinical Trials

French National Cohort MATRIX "Renal and Systemic Thrombotic Microangiopathy"

MATRIX
Start date: January 1, 2023
Phase:
Study type: Observational

Thrombotic microangiopathies (TMAs) are a diverse, rare but serious group of diseases. Progress has been made regarding the epidemiology of TMA (Bayer CJASN 2019). It has been shown that secondary TMAs account for 95% of cases, whereas primary TMAs (atypical hemolytic syndromes (HUS) and thrombotic thrombocytopenic purpura (TTP)) account for only about 5%. However, in many cases, the pathophysiology, optimal management and prognosis of TMA remains unclear and it has been shown that patients with TMA may have renal-limited TMA or renal and hematological TMA (ie. With (mechanical anemia, thrombocytopenia, elevated LDH, decreased haptoglobin, schistocytes). In most studies, kidney biopsies are not performed and the diagnostic workup is uncomplete. As this is a rare disease, only a multicenter approach (>20 centers) over a long period of time (>10 years), with adequate diagnostic workup including kidney biopsies can help us to answer these questions (investigators in the present are usually members of the CNR-MAT (a network of the TMA centers in France).

NCT ID: NCT04122222 Completed - Immunology Clinical Trials

Immune Response to Influenza Vaccine in ESRD Patients

Start date: August 25, 2016
Phase: N/A
Study type: Interventional

On-line hemodiafiltration (HDF) clears more azotaemic toxins compared to high-flux hemodialysis (HD). The response to vaccination is impaired in dialysis patients. We aimed to study the immune responses to influenza vaccine in dialysis patients treated by HDF vs. HD.

NCT ID: NCT00379899 Completed - Clinical trials for Cardiovascular Disease

ADVANCE: Study to Evaluate Cinacalcet Plus Low Dose Vitamin D on Vascular Calcification in Subjects With Chronic Kidney Disease Receiving Hemodialysis

Start date: September 2006
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate whether cinacalcet + low dose vitamin D attenuates the progression of vascular calcification over one year, compared with a treatment regimen that includes flexible vitamin D dosing in the absence of cinacalcet, in subjects with chronic kidney disease receiving hemodialysis

NCT ID: NCT00189501 Completed - Nephrology Clinical Trials

A Multi-Center, Observational Registry of Subjects With Secondary Hyperparathyroidism (HPT) and Chronic Kidney Disease (CKD)

Start date: December 2004
Phase: N/A
Study type: Observational

Objectives include description of current practices; assessment over time of K/DOQI goals, clinical outcomes, health resource utilization(HRU) and patient reported outcomes (PRO) and the impact of Sensipar® on these parameters

NCT ID: NCT00146224 Completed - Nephrology Clinical Trials

Efficacy of Epoetin Alfa Deep Tank in Treatment of Anemia in Patients With Chronic Kidney Disease Receiving Hemodialysis

Start date: September 2005
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate whether the efficacy of Epoetin alfa DT is equivalent to that of Epoetin alfa RB for the treatment of anemia in patients with CKD receiving hemodialysis