Nephrolithiasis Clinical Trial
Official title:
Mirabegron And Ureteral Stent-related Pain (MAP) Trial
Ureteric stents are used often following ureteroscopy for prevention of obstruction from
edema and/or stone fragments.
Up to 75% of patients experience pain following stenting, as well as lower urinary tract
symptoms (LUTS) such as finding blood in the urine, voiding often, the need to urinate
quickly resulting in a significant source of morbidity. The negative impact of stents results
in a significant impact on health related quality of life.
There is no standard of care for managing ureteric stent pain and lower urinary tract
symptoms following surgery. A combination of α-blockers, antimuscarinics, acetaminophen,
nonsteroidal anti-inflammatory drugs and opioids are currently the mainstay for treatment of
post-operative pain and LUTS following stenting.
Mirabegron is a beta-agonist that mediate relaxation of the detrusor muscle and has been
useful in treating overactive bladder (OAB) which has similar symptoms to patients with an
ureteric stent in place. Our goal is to assess if mirabegron can improve symptoms and
decrease the need for additional pain medications.
The investigators hypothesize that Mirabegron is effective in decreasing ureteral stent
related LUTS and pain.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Enrolling by invitation |
NCT04746378 -
PRedictive Accuracy of Initial Stone Burden Evaluation.
|
||
| Recruiting |
NCT05100017 -
Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure
|
N/A | |
| Recruiting |
NCT03692715 -
Antibiotic Prophylaxis Before Shock Wave Lithotripsy
|
Phase 4 | |
| Completed |
NCT02547805 -
Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days
|
Phase 2 | |
| Completed |
NCT02289755 -
Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria
|
Phase 2 | |
| Completed |
NCT01690039 -
Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
|
||
| Completed |
NCT01650935 -
Comparison of DASH With Oxalate Restricted Diet on Urine in Recurrent Stone Formers With Hyperoxaluria
|
N/A | |
| Completed |
NCT01295879 -
Vitamin D Repletion in Stone Formers With Hypercalciuria
|
Phase 4 | |
| Recruiting |
NCT05014178 -
Kidney Sodium Functional Imaging
|
||
| Not yet recruiting |
NCT06199102 -
The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants.
|
N/A | |
| Recruiting |
NCT04367155 -
Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.
|
N/A | |
| Recruiting |
NCT04374188 -
Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy
|
N/A | |
| Recruiting |
NCT05701098 -
SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)
|
N/A | |
| Recruiting |
NCT04389853 -
Mini-PNCL vs fURS in Management of Nephrolithiasis
|
N/A | |
| Completed |
NCT03348228 -
Effect of Hydroxycitrate on Urine Chemistry
|
N/A | |
| Completed |
NCT05350423 -
Trial Assessing Renal Damage During Ureteroscopy
|
N/A | |
| Completed |
NCT03454139 -
Subcostal TAP Block For Percutaneous Nephrolithotomy
|
N/A | |
| Recruiting |
NCT02279927 -
Prospective Comparison Between Different Laser Settings for Ureteral \ Kidney Stones Treatment During Ureteroscopy
|
N/A | |
| Completed |
NCT02276924 -
Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors
|
N/A | |
| Completed |
NCT00159393 -
Percutaneous Nephrolithotomy: A Registry and Database
|