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NCT01690039 Clinical Trial

Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis

Nephrolithiasis Clinical Trial

Official title:
Comparison of Furosemide/Fludrocortisone With Ammonium Chloride Loading Test in the Diagnosis of Incomplete dRTA in Kidney Stone Formers

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01690039
Other study ID # 090/12
Secondary ID
Status Completed
Phase
First received
Last updated
Start date September 2012
Est. completion date May 12, 2017

Study information
Verified date October 2018
Source University Hospital Inselspital, Berne
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Purpose

1. To compare the performance of the two currently employed urinary acidifications tests in stone formers, the furosemide/fludrocortisone and ammonium chloride loading test.

2. To study the impact of polymorphisms in the genes ATP6V1B1, ATP6V0A4 and SLC4A1 on urinary acidification in stone formers.

Recruitment information / eligibility
Status Completed
Enrollment 170
Est. completion date May 12, 2017
Est. primary completion date December 31, 2016
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- One or more episodes of nephrolithiasis

Exclusion Criteria:

- Absence of informed consent

- All conditions affecting renal acidification

- Pregnancy

- Nursing

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Furosemide-Fludrocortisone-Test (test for urinary acidification)
The presence of a lack of urinary acidification will be assessed by an appropriate test in all patients.

Locations
Country Name City State
Switzerland Department of Nephrology and Hypertension, Bern University Hospital Bern

Sponsors (1)
Lead Sponsor Collaborator
University Hospital Inselspital, Berne

Country where clinical trial is conducted

Switzerland, 

Outcome
Type Measure Description Time frame Safety issue
Primary Capability of urinary acidification Five to six hours
Secondary Polymorphisms in the ATP6V1 gene 12 months
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