Nephrolithiasis Clinical Trial
Official title:
Oral Antibiotic Treatment of Helicobacter Pylori Reduces Intestinal Colonization Rates With Oxalobacter Formigenes
The investigators are finding out if giving antibiotics for Helicobacter pylori will eliminate colonization of the colon by Oxalobacter formigenes.
Background and objectives: Oxalobacter formigenes (OF) may play a protective role in
preventing calcium oxalate stones. Intestinal colonization by OF is associated with reduced
urinary oxalate excretion. Exposure to antibiotics may be an important factor contributing
to variable rates of colonization. This is the first prospective study to evaluate the
effect of antibiotics on OF colonization.
Design, setting, participants, & measurements: The effect of antibiotics on OF colonization
was compared in 2 groups: a group receiving antibiotics for gastric infection with
Helicobacter pylori (HP) and a group without HP that not receiving antibiotics. OF
colonization in stool was detected by oxalate degradation at baseline and after 1 and 6
months.
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Observational Model: Case Control, Time Perspective: Prospective
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