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Nephrolithiasis clinical trials

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NCT ID: NCT06436235 Not yet recruiting - Kidney Stone Clinical Trials

Kidney Stone Inflammation

Start date: May 31, 2024
Phase:
Study type: Observational

This observational study aims to look at the connections between kidney stones, insulin resistance, and inflammation. The researchers hypothesize that people who form calcium kidney stones and have insulin resistance may have higher levels of inflammation because they have more visceral fat (fat around the abdominal organs). The study will recruit 20 people who have had calcium kidney stones but don't have diabetes, and 20 healthy people who haven't had kidney stones. All the participants will come to the research center at the University of Chicago Medicine. Participants will have a dual-energy X-ray absorptiometry (DEXA) scan to measure their visceral fat, and give blood and urine samples. The blood will be tested for insulin resistance, inflammatory markers, and other metabolic factors. The urine will be analyzed for substances that increase kidney stone risk. The main goal is to see if the kidney stone formers with insulin resistance have more visceral fat compared to those without insulin resistance and the healthy participants. The researchers will also compare inflammatory marker levels between groups, and look at how visceral fat, inflammatory markers, insulin resistance, and urine stone risk factors are related. The findings may help explain how kidney stones are connected to metabolic conditions like diabetes and cardiovascular disease. Researchers hope this information will help identify stone formers at risk early and develop preventive treatments in the future.

NCT ID: NCT06335537 Not yet recruiting - Uric Acid Stones Clinical Trials

Impact of Sodium Bicarbonate on 24-hour Urine Parameters in Hypocitriuric and Uric Acid Stone Formers

Start date: May 2024
Phase: Phase 1
Study type: Interventional

The incidence of kidney stone disease continues to rise globally. Although the treatment of kidney stone disease has dramatically improved in recent years, surgical management remains invasive and expensive. Patients who develop kidney stones are at high risk of recurrence during their lifetime; therefore, prevention of stones should be a primary focus. Low levels of citrate and acidic urine are risk factors for the formation of kidney stones such as calcium oxalate and uric acid, respectively. Calcium oxalate stones are the predominant stone composition in the United States, accounting for over 2/3rds of stones. Citrate is a key inhibitor of calcium oxalate crystal formation and thus increasing it in the urine of a calcium oxalate stone former is quite beneficial. Uric acid stones account for approximately 10 percent of all stone types. These stones form primarily due to an acidic urinary environment which is a prerequisite for crystal formation. Common medications for stone formers include potassium citrate which help to make the urine more alkaline. Although effective, these medications have side effects and may prove to be too expensive (upwards of $450/month). Consuming baking soda (sodium bicarbonate) may prove to be an inexpensive ($0.34/month) equally effective alternative with respect to increasing urinary citrate levels and alkalinizing the urine. Investigators hypothesize that twice a day oral baking soda in a liquid medium (e.g., water, orange juice, soda, etc.) can be an effective, and inexpensive alternative to urocit K with regard to alkalinizing the urine and raising urinary citrate levels.

NCT ID: NCT06288022 Not yet recruiting - Safety Issues Clinical Trials

Comparison of Total Tubeless Mini-PCNL Versus Tubeless Mini-PCNL

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

Limited literature has focused on the use of totally tubeless mini-percutaneous nephrolithotomy (Mini-PCNL) for the treatment of large renal stones. This Randomized Controlled trial aims to compare complication and safety of Mini-PCNL between total tubeless and tubeless Mini-PCNL.

NCT ID: NCT06249243 Not yet recruiting - Clinical trials for Urinary System Disorders in IBD Patients

Affection of Renal and Urinary System in IBD Patients

Start date: February 20, 2024
Phase:
Study type: Observational

Detection and classification of different renal and urinary affection in patients with IBD that attended to Assist University Hospitals

NCT ID: NCT06210009 Not yet recruiting - Kidney Stone Clinical Trials

Effect of a DASH-Style Diet on Urinary Risk Factors for Kidney Stone Disease

Start date: July 2024
Phase: N/A
Study type: Interventional

The true capacity for a healthy diet to improve urinary stone risk factors is not well-defined. The objective of this study is to measure the effect of adopting a healthy dietary pattern on kidney stone disease (KSD) risk. The working hypothesis is that a Dietary Approaches to Stop Hypertension (DASH)-style diet will improve 24-hour urine stone risk parameters. The approach to testing this hypothesis will be to randomize participants with KSD to a standardized DASH-style vs. Western-style diet for one week. The Bionutrition Unit of the Center for Clinical and Translational Science will provide all meals to participants. The rationale for this study is that by measuring the effect of a DASH-style diet on urinary stone risk parameters, a benchmark for future real-world, implementation studies will be established. Based on available evidence, this will be the first controlled diet study to assess the DASH dietary pattern for improving urinary stone risk parameters.

NCT ID: NCT06199102 Not yet recruiting - Clinical trials for Vitamin D Deficiency

The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants.

HIDVID
Start date: September 1, 2024
Phase: N/A
Study type: Interventional

The aim of this study will be to assess the effectiveness of monitored vit D supplementation in a population of preterm infants and to identify whether the proper vit D supplementation in preterm infants can reduce the incidence of neonatal sepsis and incidence of metabolic bone disease.

NCT ID: NCT06185387 Not yet recruiting - Renal Stone Clinical Trials

Changes Post Percutaneous Nephrolithotomy

KUB
Start date: March 1, 2024
Phase:
Study type: Observational [Patient Registry]

Using color doppler U/S, Abdominal U/S and radioisotope to evaluate changes of renal morphology, function and doppler parameters post Percutaneous nephrolithotomy

NCT ID: NCT06178575 Not yet recruiting - Kidney Calculi Clinical Trials

Apply Machine Learning to the Interpretation of Urinary Crystal Morphology.

Start date: January 1, 2024
Phase:
Study type: Observational

The goal of this observational study is to developing an image-based artificial intelligence software that can automatically interpret the types and sizes of crystals in urine. The main question[s] it aims to answer are: - Allowing healthcare professionals to input urine images and receive real-time reading results on crystal types and sizes. - This aims to provide a faster, more objective, and accurate analysis of crystals. We anticipate delivering an image AI software suitable for practical applications, promoting the automation and accuracy of urine crystal analysis.

NCT ID: NCT06149455 Not yet recruiting - Nephrolithiasis Clinical Trials

Preoperative Prophylactic Antibiotic Duration in Moderate to High Risk Ureteroscopy

Start date: January 1, 2024
Phase: N/A
Study type: Interventional

The goal of this non-inferiority randomized controlled trial: is to test the hypothesis that the that there is no additional benefit from a longer course (7 days) versus a shorter course (2 days) of pre-operative antibiotics in patients with moderate to high risk of infection undergoing ureteroscopy. The main questions it aims to answer are: 1. Determine the safety and efficacy of a short course (2 days) as compared to a long course (7 days) 2. Identify secondary predictors of post-operative infectious complications

NCT ID: NCT06131151 Not yet recruiting - Renal Stone Clinical Trials

Comparison Between External Oblique Intercostal Block and Erector Spinae Plane Block in PCNL

Start date: November 2023
Phase: N/A
Study type: Interventional

The aim of the study is to compare the post-operative analgesic effect of USG unilateral External oblique intercostal (EOI) block with Erector spinae plane block (ESPB) for after percutaneous Nephrolithotomy with a hypothesis that both External oblique intercostal fascial plane block and Erector spinae plane block are effective in providing postoperative analgesia.