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Nephrolithiasis clinical trials

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NCT ID: NCT06394219 Completed - Large Renal Stone Clinical Trials

A Comparative Study Between Anterior and Posterior Pyelotomy in Transperitoneal Laparoscopic Pyelolithotomy

Start date: January 1, 2022
Phase: N/A
Study type: Interventional

Large renal pelvic stones are frequently managed with percutaneous nephrolithotomy (PCNL) but laparoscopic pyelolithotomy (LPL) can be an alternative procedure when performed by skilled surgeons to achieve excellent outcomes in terms of stone free status, operative time, postoperative kidney function, hospitalization duration, and complications. there are two methods for LPL surgery : Transperitoneal (TLP) and Retroperitoneal (RLP). RLP associated with shorter mean time for oral intake, and mean hospital stay after surgery. The surgical exposure in the transperitoneal route for LP is familiar to the majority of surgeons. Also, a much larger working space is available and there are various established anatomical landmarks for performing the surgery effectively. This study introduces a modified technique that creates application of posterior pyelotomy in TLP to achieve the advantages of RLP

NCT ID: NCT06381206 Completed - Stone, Kidney Clinical Trials

Silodosin in Management of Lower Ureteral Stones

Start date: October 20, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This research aims to study the effectiveness of silodosin in the management of lower ureter stones larger than 6 mm in diameter in terms of affected ureter (right or left), the size of the stone, the degree of hydronephrosis, the rate of stone expulsion(day), whether the stone was completely expelled or not, and the side effects of silodosin.

NCT ID: NCT06338137 Completed - Renal Stone Clinical Trials

Comparison of High and Low Pulse Energy Dusting Protocols Using Holmium: YAG-laser in Flexible Ureteroscopy for Renal Stones Treatment

Start date: August 25, 2022
Phase: N/A
Study type: Interventional

Rcompare high-energy versus low-energy laser settings in renal stone lithotripsy using low power machines) Holmium YAG 30 watts, examining their respective advantages, limitations, and overall efficacy.

NCT ID: NCT06175910 Completed - Renal Stones Clinical Trials

Postoperative Outcomes of PCNL vs RIRS in Obese Patients With Pelvic 1.5:3 cm Renal Stones

PCNL VS RIRS
Start date: December 2, 2020
Phase: N/A
Study type: Interventional

This prospective randomized comparative study was done at Helwan University Hospital. It was conducted on 120 patients with unilateral pelvic renal stones from 1.5 to 3 cm in largest diameter who was admitted through duration to compare the two procedures differences in terms of complications, analgesic use, hospital stay, operational time, and stone-free rates.

NCT ID: NCT06138704 Completed - Renal Stone Clinical Trials

Evaluation of Retrograde Intrarenal Surgery Results and Stone-free Rate in Children With Kidney Stones

Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

There is a global increase in the prevalence of urolithiasis in children attributed to lifestyle changes, dietary habits, climate changes, childhood obesity, and the wider availability of ultrasonography. The rising incidence of the disease with its recurrent nature emphasizes the need for minimally invasive therapeutic options. Patients in whom RIRS has been performed in the last four years with increasing experience will be presented, and complications, stone-free rates, and technical details will be discussed. This retrospective Cohort study included children who underwent RIRS. Medical history, serum electrolytes, midstream urine culture, urinalysis, serum creatinine, complete blood count, and coagulation assessments were performed preoperatively. Ultrasonography (USG) was performed three months, 6 months, and 1 year after the procedures to evaluate stone recurrence and hydronephrosis. The investigators analyzed the stone-free rate ,complications, and the conversion to open procedure

NCT ID: NCT06122129 Completed - Clinical trials for Flexible Ureteroscopy

Flexible Ureteroscopy With and Without Ureteral Access Sheath in Treatment of Large Renal Stones

Start date: November 8, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the flexible ureteroscope (FURS) technique with and without ureteral access sheath (UAS).

NCT ID: NCT06120257 Completed - Renal Stones Clinical Trials

Management of Lower Pole Renal Hard Stones ≤2 cm

Start date: March 1, 2022
Phase: N/A
Study type: Interventional

The study has been conducted in Urology department at Kafrelsheikh University Hospital between March 2022 to March 2023. informed consent was taken from eligible patients and were randomized into three groups, Group A :Flexible ureteroscope (F-URS) group underwent holmium laser lithotripsy using flexible ureteroscopy (Boston® scientific (lithovue) while, Group B : extracorporeal shock wave lithotripsy (ESWL) group underwent electromagnetic extracorporeal shock wave lithotripsy (STORZ® MEDICAL Modulith SLX-F2 FD21, Germany) .Group C : Mini perc group underwent holmium laser lithotripsy using Karl® Storz MIP set.

NCT ID: NCT06031103 Completed - Stone, Kidney Clinical Trials

Clinical Efficacy of Mini-PCNLversus RIRS for the Management of Upper Urinary Tract Calculus (1-2.5 cm)

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

The goal of this [ type of study:]prospective randomized clinical trial. The main question is to compare the outcomes of mini-percutaneous nephrolithotomy (m-PCNL) and retrograde intrarenal surgery (RIRS) in treating upper urinary tract calculus in children ≤ 10 years.

NCT ID: NCT05972408 Completed - Renal Calculi Clinical Trials

Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based Stones Among Patients With Renal Calcular Disease in Mansoura Urology and Nephrology Center

Start date: March 21, 2021
Phase:
Study type: Observational

Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based stones among Patients with Renal Calcular Disease in Mansoura Urology and Nephrology Center

NCT ID: NCT05911945 Completed - Kidney Calculi Clinical Trials

Failed Insertion of Ureteral Access Sheath During Flexible Ureterorenoscopy

Start date: September 10, 2020
Phase: N/A
Study type: Interventional

Percutaneous nephrolithotomy (PNL) is the gold standard recommended treatment technique for kidney stones larger than 20 mm. For kidney stones between 10 - 20 mm, both shock wave lithotripsy (SWL) or flexible ureterorenoscopy (f-URS) are recommended as the first choice of treatment and PNL is recommended as the second. In patients who are planned to undergo f-URS, a ureteral access sheath (UAS) is placed in the ureter at the beginning of the operation in order to provide a better image, reduce intra-renal pressure, easier stone fragment retrieval and shorter operative time. In certain cases, such as ureteral stricture, kink or edema, the ureteral access sheath may not be able to successfully inserted into the ureter. At this stage, double-J (JJ) stent can be inserted into the ureter to create passive dilatation, and a second f-URS session can be scheduled a few weeks later. Another option is to perform PNL operation to the patient in the same session. In this randomized prospective study, we aimed to compare these two different surgical approaches in terms of patient comfort and surgical success in patients with kidney stones between 10 - 20 mm in which access sheath insertion was failed in the initial f-URS session.