Neuroblastoma Clinical Trial
Official title:
The Role of Stroma-Derived Soluble TßRIII in Neuroblastoma
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies gene expression in samples from younger patients with
neuroblastoma.
OBJECTIVES:
- Determine whether TβRIII expression and TGF-β signaling decrease in advanced-stage
neuroblastoma (NBL) and whether these changes are confined to the Schwannian stroma.
- Determine whether sTβRIII levels and TGF-β signaling correlate with NBL stage, tumor
stroma content, surface TβRIII expression, and TGF-β signaling.
OUTLINE: Archived paraffin-embedded tissue and plasma samples are analyzed for TβRIII
expression, TGF-β signaling, and SMAD3 expression and phosphorylation by
immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), and other assays. Surface
expression of TβRIII in the neuroblastic and stromal tumor components are correlated with
matched circulating levels of soluble TβRIII. Results are then correlated with each
patient's outcome data, including stage.
;
Observational Model: Case Control, Time Perspective: Prospective
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