Cancer Clinical Trial
Official title:
The Value of Molecular Biological Analysis of Blood Samples in Standardized Care Procedures in Suspected Cancer (SCAN) and Cancer of Unknown Primary (CUP)
Patients with suspected cancer (SCAN) and cancer of unknown primary tumor (CUP) are
vulnerable because the investigation is difficult and expensive and have poor prognosis
because few effective established curative treatments are available. Great progress has been
made, for example through highly qualified and systematic clinical investigations not least
within the framework of the standardized care processes. However, there is a need for faster,
less invasive and more cost-effective tests to confirm or exclude the diagnosis of carcinoma
(epithelial cancer), primarily for SCAN and secondly for CUP, and partly to receive
suggestions for localization of the primary tumor for primarily CUP and secondly SCAN. There
is also a need for prediction of molecularly targeted therapies.
New research provides opportunities for using a blood test to acquire detailed and updated
information about the individual patient's disease and thus also open new opportunities for
faster, less invasive and more cost-effective diagnosis and prediction of molecularly
targeted treatments based on individualized sampling and molecular stratification. It is
important that these opportunities are tested in a timely fashion in practical health care,
so the new opportunities can be taken advantage of and developed in the best way. The aim is
to establish a new "best practice" for these hard-to-study and difficult-to-treat patients.
Samples will be taken of epithelial cells circulating in the blood, and of the free
circulating DNA.
As a reference, germ-line DNA will also be sampled, also from regular blood samples.
The analyses will show whether the cellular and molecular tests can work in the existing
standardized care processes for SCAN and CUP, or if adaptations in routines, training or
equipment need to be introduced.
The analyses will also give an indication of whether the cellular and molecular sample
analyses provide practically useful information for confirming or refuting the diagnosis of
cancer, suggesting from which organ the cancer originated and for predicting individualized
therapies, and whether adaptations in routines, training or technology need to be introduced.
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