Metastatic Spinal Cord Compression (MSCC): Treatment Timing and Survival Rate

Neoplasm Metastasis Clinical Trial

Official title:

Metastatic Spinal Cord Compression (MSCC): Treatment Timing and Survival Rate

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT02934594
• Other study ID #: 201608007RIND
• Status: Not yet recruiting
• Phase: N/A
• First received: October 11, 2016
• Last updated: October 13, 2016
• Start date: October 2016
• Est. completion date: August 2020

Study information

• Verified date: October 2016
• Source: National Taiwan University Hospital
• Contact: Shu-Hua Yang, M.D., Ph.D.
• Phone: 886-2-23123456
• Email: 005964[@]ntuh.gov.tw
• Is FDA regulated: No
• Health authority: Taiwan: Ministry of Health and Welfare
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Patients with metastatic spinal cord compression (MSCC) are treated with different options according to the life expectancy. Survival and surgical outcome can be influenced by surgical timing in MSCC patients treated with palliative decompression.

Description:

MSCC patients who underwent palliative decompression after January 2012 in National Taiwan University Hospital (NTUH) were divided into the preoperative motor function intact group (Group A) and motor deficit group (Group B). The motor deficit group was subdivided into operation within 48 hours (Group B1), and after 48 hours (Group B2). All patients underwent palliative decompression and posterior stabilization. Investigators did wide laminectomy for tumor invading the vertebral body, and debulking surgery for tumor destructing the posterior column of the spine. Investigators retrospectively reviewed all patient records, including patient demographics, prognostic factors for survival (Kaplan-Meier survival analysis), neurological outcome (Frankel grade), primary tumor, complications, and relevance of Tomita and Tokuhashi scores.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 500
• Est. completion date: August 2020
• Est. primary completion date: August 2020
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 21 Years to 99 Years

Eligibility

Inclusion Criteria:

• Patients with metastatic spinal cord compression (MSCC) who underwent palliative decompression in National Taiwan University Hospital after January 1st, 2012.

Exclusion Criteria:

• Patients with metastatic spinal cord compression (MSCC) who underwent palliative decompression before December 31st, 2011, or those who were not treated in National Taiwan University Hospital.

Study Design

Observational Model: Case-Only

Related Conditions & MeSH terms

• Neoplasm Metastasis
• Spinal Cord Compression

Intervention

Other:
• Palliative Decompression
palliative decompression to MSCC patients: before motor deficit (Group A), within 48 hours after motor deficit (Group B1), 48 hours after motor deficit (Group B2)

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

References & Publications (2)

Tokuhashi Y, Matsuzaki H, Oda H, Oshima M, Ryu J. A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine (Phila Pa 1976). 2005 Oct 1;30(19):2186-91. — View Citation

Tomita K, Kawahara N, Kobayashi T, Yoshida A, Murakami H, Akamaru T. Surgical strategy for spinal metastases. Spine (Phila Pa 1976). 2001 Feb 1;26(3):298-306. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	survival rate		5 years	No