Autologous Cord Blood Cells for Prevention of BPD in Preterm

Status Completed

Clinical Trial Summary

To study the effect of Autologous cord blood cells infusion on prevention of bronchopulmonary dysplasia in very preterm neonates

Clinical Trial Description

We did a randomized, double-blind, placebo-controlled trial to assess effect of one intravenous dose of cord blood MNCs compared with placebo in reducing incidence of BPD in very preterm neonates.We enrolled preterm neonates less than 32 weeks of GA at neonatal intensive care units (NICUs) in Guangdong Women and Children Hospital within the first 24 postnatal hours. Patients were randomly assigned by 1:1 to receive either (5×107cells/kg ACBMNC or normal saline intravenously within 24 hours after birth according to a computer-generated schedule. The primary endpoint was efficacy at 36 GA or discharge home and all analyses were done by intention to prevent.MNCs viability was also tested before transfusion ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04311476
Study type	Interventional
Source	Guangdong Women and Children Hospital
Contact
Status	Completed
Phase	Phase 2
Start date	July 1, 2018
Completion date	January 1, 2020

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