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Vagal Tone and Neonatal Abstinence Syndrome — NAS  

Neonatal Abstinence Syndrome Clinical Trial

Official title:
Vagal Tone and Neonatal Abstinence Syndrome

Clinical Trial Summary

Symptoms of Neonatal Abstinence Syndrome (NAS) can be attributed largely to dysfunction of the autonomic nervous system in opiate exposed neonates. Vagal tone is a readily available measure of autonomic nervous system functioning. NAS is a widely variable disorder with poorly understood pathophysiology; while all opiate exposed infants will exhibit some signs and symptoms of NAS, only approximately ½ have severe enough symptoms to require pharmacologic therapy. This research seeks to determine the relationship between infant vagal tone and NAS severity. The determination of a link between newborn vagal tone and NAS severity could result in the prediction of infants at risk for severe NAS and provide these infants and mothers with intensified services and early treatment, thereby shortening the course of NAS in the infant.

Clinical Trial Description

Consecutively born methadone exposed infants had hert period and cardiac vagal tone measurements extracted via standard EKGs on days 1 and 3 of life. The infant's NAS course was assessed serially. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00496951
Study type Observational
Source Johns Hopkins University
Contact
Status Completed
Phase N/A
Start date September 2006
Completion date September 2008
View Details
See also
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