Clinical Trials Logo
  1. Home
  2. Neck Cancer
  3. NCT05551767

Induction Immunochemotherapy in Stage III-IVa Head and Neck Cancer

Neck Cancer Clinical Trial

Official title:
Induction Immunochemotherapy in Stage III-IVa Cancer of Oropharynx, Hypopharynx and Larynx

Clinical Trial Summary

patients with locally advanced cancer of oropharynx, hypopharynx or larynx and CPS>1 will recieve 3 cycles of induction immunochemotherapy with platinum, 5-FU and pembrolizumab followed by (chemo)radiation.

Clinical Trial Description

patients with locally advanced cancer of oropharynx, hypopharynx or larynx and CPS>1 will recieve 3 cycles of induction immunochemotherapy with platinum (cisplatin 75 mg\m2, 5-FU 1000 mg/m2/day 96-hour infusion and pembrolizumab 200 mg) followed by (chemo)radiation. Effect of induction therapy will be assesed by PET/CT and by endoscopic evaluation with biopsy of suspected residual tumor. Managemant of any residual tumor will be performed according with local rules and standards. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05551767
Study type Interventional
Source City Clinical Oncology Hospital No 1
Contact Ilya ? Pokataev
Phone +79262858986
Email pokia@mail.ru
Status Recruiting
Phase Phase 2
Start date August 30, 2022
Completion date December 30, 2024
View Details
See also
  Status Clinical Trial Phase
Completed NCT05746780 - Bilateral Elective Neck Dissection in Salvage Total Laryngectomy
Recruiting NCT04708470 - A Phase I/II Study of Combination Immunotherapy for Advanced Cancers Including HPV-Associated Malignancies, Small Bowel, and Colon Cancers Phase 1/Phase 2
Completed NCT00318890 - Cisplatin and Docetaxel Plus Docetaxel and Radiotherapy With Amifostine for Squamous Cell Carcinoma of the Head and Neck Phase 1/Phase 2
Completed NCT00798655 - Trial of Postoperative Radiation, Cisplatin, and Panitumumab in Locally Advanced Head and Neck Cancer Phase 2
Completed NCT06010381 - Muscle Energy Technique Versus Maitland Mobilization on Shoulder Pain and Disability N/A
Recruiting NCT06432998 - Perineal Massage in Women With Gynecological Cancer N/A
Completed NCT02714920 - DNA Repair Enzyme Signature in Head and Neck Cancer (CHEMRAD) N/A
Terminated NCT01910753 - Physical Activity Program and Nutrition Therapeutic Education During Treatment of Head and Neck Cancer Population N/A
Completed NCT01194466 - Transcutaneous Electrical Nerve Stimulation (TENS) and Head and Neck Cancer Pain (HNC) (TENS & HNC) N/A
Recruiting NCT03530033 - Lidocaine Reduces Muscle Tremor is Beneficial for Intraoperative Recurrent Laryngeal Nerve Monitoring N/A
Recruiting NCT05549414 - Pivotal Study of Proton Radiotherapy Treatments Using Fixed Beam Chair-Based Delivery System N/A
Recruiting NCT04750434 - PET MRI as a Staging Tool for Head and Neck Cancer
Withdrawn NCT05472506 - Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck Cancer Phase 1
Not yet recruiting NCT04261179 - Study Comparing Lymphoseek® vs. Albumin Nanocolloid in Head and Neck, Melanoma and Breast Cancer Phase 4
Completed NCT00723463 - Determine if Apparent Diffusion Coefficient (ADC) Values Can Differentiate Tumors From Normal Tissue Phase 0
Recruiting NCT04673981 - Neurosensorial Disorder and Pain in Oral Cavity and Oropharynx Cancer Traited Patients (OCAPA) N/A
Not yet recruiting NCT05946577 - Association Between Tinnitus and Hearing Loss in Locally Advanced Head and Neck Cancer Treated by Radiotherapy Alone or With Chemotherapy: a Prospective and Multicenter Study
Completed NCT05246891 - Rehabilitation Nursing Program in Otolaryngology
Completed NCT02738268 - Laser Therapy for the Prevention of Radiodermatitis in Head and Neck Patients N/A
Recruiting NCT04722523 - A Study of Cemiplimab With Chemotherapy and Immunotherapy in People With Head and Neck Cancer Phase 1